DYNLL2 and RASGRP3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DYNLL2	RASGRP3
Gene Name		dynein, light chain, LC8-type 2	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol Microtubule Plasma Membrane Membrane Myosin Complex Dynein Complex Primary Cilium Ciliary Tip	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Motor Activity Protein Binding Cytoskeletal Protein Binding	Signal Transducer Activity Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Ras GTPase Binding Kinase Binding Diacylglycerol Binding Rap GTPase Activator Activity
	Biological Process	Transport Apoptotic Process Organelle Organization Microtubule-based Process Synaptic Target Recognition Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity
Pathways		Organelle biogenesis and maintenance MHC class II antigen presentation Programmed Cell Death Activation of BH3-only proteins Assembly of the primary cilium Intraflagellar transport Adaptive Immune System Intrinsic Pathway for Apoptosis Activation of BMF and translocation to mitochondria	Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of RAS in B cells Adaptive Immune System
Drugs
Diseases
GWAS			Hypertension (young onset) ( 19421330) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		20 interactors: BCL2L11 BMF C12orf40 CCDC36 DLGAP1 DNAL4 DYNC1I1 EWSR1 GPHN GPRIN2 HMBOX1 HOMER3 MEOX2 MORN3 MYO5A PAK1 RASGRP3 SECISBP2L THAP10 XIAP	9 interactors: APP DYNLL2 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		140735	25780
HPRD ID		06489	15213
Ensembl ID			ENSG00000152689
Uniprot IDs		Q96FJ2	Q8IV61
PDB IDs		2XQQ 3P8M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Homooligomerization Positive Regulation Of Protein Oligomerization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Synapse Organization Regulation Of Protein Oligomerization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cell Death Death Regulation Of Intracellular Signal Transduction Receptor Clustering Neuromuscular Junction Development Positive Regulation Of Mitochondrion Organization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Developmental Pigmentation Positive Regulation Of Cellular Component Biogenesis Apoptotic Signaling Pathway Protein Localization To Membrane Membrane Organization Positive Regulation Of Protein Linear Polyubiquitination Signaling Regulation Of Mitochondrion Organization Cellular Localization Positive Regulation Of Organelle Organization Cell Communication Vesicle Transport Along Actin Filament Establishment Of Synaptic Specificity At Neuromuscular Junction Endoplasmic Reticulum Localization Apoptotic Process Pigmentation Programmed Cell Death Apoptotic Process Involved In Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process By Virus Odontogenesis Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Fibroblast Apoptotic Process Somite Specification Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Thymocyte Apoptotic Process Anoikis Locomotion Involved In Locomotory Behavior Histone H3-T11 Phosphorylation	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cellular Response To Insulin Stimulus Regulation Of Platelet Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune System Process Protein Phosphorylation Regulation Of Wound Healing Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Histone H3-T6 Phosphorylation Regulation Of Platelet Activation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Peptidyl-threonine Phosphorylation Phosphorylation Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Activation Of Phospholipase C Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase C Activity Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Positive Regulation Of Phospholipase Activity
Tagcloud ?		associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynlrb1 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60	activating arthritis cas9 colitis coupling crispr destruct dextrane editing elucidated excessive gtpases guanine impairs invading limits nucleotide rap rap1 raw264 releasing relieves sulphate switches threshold tlr tlr3 toll
Tagcloud (Difference) ?		associates bicd2 bona chains cilia ciliopathies ciliopathy define dynactin dynein dynlrb1 dynlt1 dynlt3 encoded fide ift intraflagellar lc8 lis1 nudcd3 pafah1b1 retrograde roadblock tctex tctex1d2 wdr34 wdr60	activating arthritis cas9 colitis coupling crispr destruct dextrane editing elucidated excessive gtpases guanine impairs invading limits nucleotide rap rap1 raw264 releasing relieves sulphate switches threshold tlr tlr3 toll
Tagcloud (Intersection) ?