DYNLL2 and RASGRP3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		DYNLL2	RASGRP3
Description		dynein light chain LC8-type 2	RAS guanyl releasing protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Microtubule Associated Complex Plasma Membrane Cilium Postsynaptic Density Microtubule Cytoskeleton Membrane Dynein Complex Myosin V Complex Ciliary Tip 9+0 Non-motile Cilium Postsynapse Glutamatergic Synapse	Cytoplasm Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Scaffold Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Kinase Binding Diacylglycerol Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Microtubule-based Process	MAPK Cascade Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838193 23273568 26663301 27399966 28714469 33272962)
Interacting Genes		30 interacting genes: BMF C14orf119 DLGAP1 DNAL4 DPPA3 DYNC1I1 EWSR1 FAM117B GABARAPL2 GPHN GPRIN2 HDAC6 HOMER3 IHO1 MEOX2 MORN3 MYO5A OTUD6A PAK1 PKIA PKIG RASGRP3 REDIC1 SKAP1 SMCP SPAG8 THAP10 TPPP XIAP ZAR1	11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		140735	25780
HPRD ID		06489	15213
Ensembl ID		ENSG00000264364	ENSG00000152689
Uniprot IDs		Q96FJ2	Q8IV61
PDB IDs		2XQQ 3P8M 4D07 7CNU
Enriched GO Terms of Interacting Partners?		Microtubule Binding	Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Positive Regulation Of Establishment Of Protein Localization Kinase Activity Cell Activation Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Peptidyl-serine Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Signaling Pathway Regulation Of Protein Transport Fc Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Protein Kinase Activity Regulation Of Protein Localization Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Cytosol Leukocyte Activation Positive Regulation Of Insulin Secretion Positive Regulation Of Immune System Process Insulin Receptor Substrate Binding Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Cellular Response To Hormone Stimulus Perinuclear Region Of Cytoplasm Protein Phosphorylation Regulation Of Biological Quality Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process
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