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HAPLN1 and MMP2
Number of citations of the paper that reports this interaction (PubMedID
7694569
)
30
Data Source:
HPRD
(in vitro)
HAPLN1
MMP2
Description
hyaluronan and proteoglycan link protein 1
matrix metallopeptidase 2
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Matrix
Synapse
Perineuronal Net
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Mitochondrion
Plasma Membrane
Membrane
Sarcomere
Extracellular Matrix
Molecular Function
Hyaluronic Acid Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Fibronectin Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Zinc Ion Binding
Hydrolase Activity
Metal Ion Binding
Biological Process
Skeletal System Development
Cell Adhesion
Central Nervous System Development
Angiogenesis
Ovarian Follicle Development
Ovulation From Ovarian Follicle
Luteinization
Response To Hypoxia
Blood Vessel Maturation
Intramembranous Ossification
Proteolysis
Response To Oxidative Stress
Negative Regulation Of Cell Adhesion
Heart Development
Female Pregnancy
Embryo Implantation
Parturition
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Peripheral Nervous System Axon Regeneration
Response To Activity
Cell Migration
Extracellular Matrix Disassembly
Protein Catabolic Process
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Response To Retinoic Acid
Response To Cytokine
Cellular Response To Reactive Oxygen Species
Response To Nicotine
Endodermal Cell Differentiation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Response To Estrogen
Negative Regulation Of Vasoconstriction
Ephrin Receptor Signaling Pathway
Macrophage Chemotaxis
Positive Regulation Of Smooth Muscle Cell Proliferation
Skeletal System Morphogenesis
Tissue Remodeling
Response To Electrical Stimulus
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Prostate Gland Epithelium Morphogenesis
Trophoblast Cell Migration
Cellular Response To Amino Acid Stimulus
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-1
Cellular Response To Estradiol Stimulus
Cellular Response To UV-A
Cellular Response To Fluid Shear Stress
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways
ECM proteoglycans
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells
Interleukin-4 and Interleukin-13 signaling
Extra-nuclear estrogen signaling
Drugs
Hyaluronic acid
Marimastat
Captopril
SC-74020
Halofuginone
AE-941
Endostatin
Oleandrin
Diseases
Choriocarcinoma
Penile cancer
Torg-Winchester syndrome
GWAS
Ankylosing spondylitis (
22138694
)
Blood protein levels (
30072576
)
Carotid intima media thickness (mean) (
31801372
)
Diisocyanate-induced asthma (
25918132
)
Gastroesophageal reflux disease (
31527586
)
Metabolite levels (
23823483
)
Prostate cancer (
17903305
)
Visceral fat (
22589738
)
Waist circumference (
28552196
)
White matter integrity (fractional anisotropy) (
29752348
)
White matter integrity (mean diffusivity) (
29752348
)
Heel bone mineral density (
30598549
)
Lack of premeditation (
30718321
)
Refractive error (
32231278
)
Interacting Genes
8 interacting genes:
ACAN
APP
MMP10
MMP2
MMP3
MMP7
MMP9
VCAN
40 interacting genes:
A2M
ACAN
BACE1
BCAN
CAPN3
CCL7
CCN5
CLDN1
COL18A1
COL1A1
COL6A3
COL7A1
CXCL12
DCN
EPHB2
FGFR1
HAPLN1
HSP90AA1
IGFBP3
IL1B
ITGAV
KISS1
LCN2
LGALS3
MMP14
MMP17
MMP25
MTDH
MTNR1A
MTNR1B
PZP
REL
SPOCK1
TGFB1
THBS1
THBS2
TIMP1
TIMP2
TIMP3
TIMP4
Entrez ID
1404
4313
HPRD ID
00275
00386
Ensembl ID
ENSG00000145681
ENSG00000087245
Uniprot IDs
P10915
P08253
PDB IDs
1CK7
1CXW
1EAK
1GEN
1GXD
1HOV
1J7M
1KS0
1QIB
1RTG
3AYU
7XGJ
7XJO
8H78
Enriched GO Terms of Interacting Partners
?
Collagen Catabolic Process
Extracellular Matrix Disassembly
Extracellular Matrix
Collagen Metabolic Process
Extracellular Matrix Organization
Extracellular Structure Organization
Endopeptidase Activity
Metalloendopeptidase Activity
Metallopeptidase Activity
Extracellular Space
Serine-type Endopeptidase Activity
Cellular Response To UV-A
Response To Amyloid-beta
Response To UV-A
Extracellular Region
Peptidase Activity
Proteolysis
Cellular Response To UV
Response To Light Stimulus
Perineuronal Net
Golgi Lumen
Cellular Response To Light Stimulus
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Protein Metabolic Process
Regulation Of Cell Migration
Response To Radiation
Central Nervous System Development
Regulation Of Cell Motility
Response To UV
Regulation Of Locomotion
Hyaluronic Acid Binding
Cellular Response To Radiation
Skeletal System Development
Regulation Of Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Metal Ion Binding
Endodermal Cell Differentiation
Regulation Of Neuroinflammatory Response
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Embryo Implantation
Ephrin Receptor Signaling Pathway
Hydrolase Activity
Cellular Response To Oxygen-containing Compound
Amyloid-beta Complex
Growth Cone Lamellipodium
Regulation Of Response To Calcium Ion
Positive Regulation Of Neuron Apoptotic Process
Amylin Binding
Extracellular Matrix
Extracellular Space
Extracellular Region
Peptidase Inhibitor Activity
Protease Binding
Metalloendopeptidase Inhibitor Activity
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Regulation Of Cell Motility
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Locomotion
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Membrane Protein Ectodomain Proteolysis
Cell Adhesion
Positive Regulation Of Developmental Process
Response To Cytokine
Response To Peptide
Positive Regulation Of Mononuclear Cell Migration
Response To Hormone
Skeletal System Development
Regulation Of Apoptotic Process
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Regulation Of Multicellular Organismal Process
Positive Regulation Of Multicellular Organismal Process
Negative Regulation Of Cell Adhesion
Regulation Of Programmed Cell Death
Cell Migration
Extracellular Matrix Binding
Regulation Of Mononuclear Cell Migration
Integrin Binding
Positive Regulation Of Leukocyte Migration
Perineuronal Net
Negative Regulation Of Multicellular Organismal Process
Serine-type Endopeptidase Inhibitor Activity
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Response To Carbohydrate
Regulation Of Proteolysis
Regulation Of Developmental Process
Basement Membrane
Regulation Of Cell Junction Assembly
Regulation Of Anatomical Structure Morphogenesis
Cell Motility
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Developmental Process
Golgi Lumen
Response To Xenobiotic Stimulus
Negative Regulation Of Metallopeptidase Activity
Angiogenesis
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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