HAPLN1 and MMP7

Number of citations of the paper that reports this interaction (PMID 7694569)
9

Data Source:
HPRD (in vitro)

		HAPLN1	MMP7
Gene Name		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 7 (matrilysin, uterine)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding	Metalloendopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Regulation Of Cell Proliferation Response To Drug Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		ECM proteoglycans	Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Prostate cancer ( 17903305) Visceral fat ( 22589738)	Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	16 interactors: BCAN CD151 CD44 DCN FASLG HAPLN1 HBEGF MBP MMP1 MMP9 NGF PLG SERPINA1 SPP1 TFPI TNFSF11
Entrez ID		1404	4316
HPRD ID		00275	01525
Ensembl ID		ENSG00000145681	ENSG00000137673
Uniprot IDs		P10915	P09237
PDB IDs			1MMP 1MMQ 1MMR 2DDY 2Y6C 2Y6D
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Proteolysis Protein Metabolic Process Skeletal System Development Endodermal Cell Differentiation Ossification Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Axon Guidance Embryo Implantation Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Endoderm Development Nervous System Development Locomotion Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Axonogenesis Response To Amino Acid Synaptic Growth At Neuromuscular Junction Axon Development Cell Recognition Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Collateral Sprouting In Absence Of Injury Neuron Projection Morphogenesis Regulation Of Protein Binding Regulation Of Locomotion Regulation Of Cellular Component Movement Organ Development Positive Regulation Of Receptor Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Neurogenesis Cell Morphogenesis Involved In Differentiation Cellular Response To Acid Chemical Glycosaminoglycan Metabolic Process	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Leukocyte Migration Cell Migration Cell Motility Wound Healing Response To Wounding Immune System Process Locomotion System Development Response To Stress Movement Of Cell Or Subcellular Component Multicellular Organismal Development Organ Development Regulation Of Endopeptidase Activity Positive Regulation Of Keratinocyte Migration Anatomical Structure Development Regulation Of Peptidase Activity Blood Coagulation Hemostasis Glycosaminoglycan Catabolic Process Response To External Stimulus Response To Organic Substance Pathogenesis Response To Lipid Response To Bacterium Developmental Process Dermatan Sulfate Biosynthetic Process Regulation Of Body Fluid Levels Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Response To Lipopolysaccharide Positive Regulation Of Bone Resorption Regulation Of Proteolysis Response To Molecule Of Bacterial Origin Tissue Development Response To Other Organism Response To Biotic Stimulus Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Axonogenesis Defense Response Inflammatory Response Response To Stimulus Positive Regulation Of Tissue Remodeling Glycosaminoglycan Metabolic Process Response To Steroid Hormone
Tagcloud ?		aabs ac adenocarcinoma antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	a549 a549cis a549cisdkk3 adenocarcinoma betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Difference) ?		aabs ac antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	a549 a549cis a549cisdkk3 betacatenin calu1 calu1cis chemosensitivity cisplatin cisplatinresistant cisplatintreated cmyc dickkopf3 dkk3 ecadherin enhances h460 h460cis h460cisdkk3 inactivated parp proportions reactivation realize rendered retarded sb216763 seeded subline
Tagcloud (Intersection) ?		adenocarcinoma