HAPLN1

Description		hyaluronan and proteoglycan link protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development
Pathways		ECM proteoglycans
Drugs		Hyaluronic acid
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN
Entrez ID		1404
HPRD ID		00275
Ensembl ID		ENSG00000145681
Uniprot IDs		P10915
PDB IDs
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Endopeptidase Activity Metalloendopeptidase Activity Metallopeptidase Activity Extracellular Space Serine-type Endopeptidase Activity Cellular Response To UV-A Response To Amyloid-beta Response To UV-A Extracellular Region Peptidase Activity Proteolysis Cellular Response To UV Response To Light Stimulus Perineuronal Net Golgi Lumen Cellular Response To Light Stimulus Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein Metabolic Process Regulation Of Cell Migration Response To Radiation Central Nervous System Development Regulation Of Cell Motility Response To UV Regulation Of Locomotion Hyaluronic Acid Binding Cellular Response To Radiation Skeletal System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Ephrin Receptor Signaling Pathway Hydrolase Activity Cellular Response To Oxygen-containing Compound Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding
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