HAPLN1 and ACAN

Number of citations of the paper that reports this interaction (PMID 12888576)
21

Data Source:
HPRD (in vitro)

		HAPLN1	ACAN
Gene Name		hyaluronan and proteoglycan link protein 1	aggrecan
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		ECM proteoglycans
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Prostate cancer ( 17903305) Visceral fat ( 22589738)	Height ( 21998595 20881960 23563607 18391952)
Protein-Protein Interactions		8 interactors: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN
Entrez ID		1404	176
HPRD ID		00275	01123
Ensembl ID		ENSG00000145681	ENSG00000157766
Uniprot IDs		P10915	E7ENV9 E7EX88
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Proteolysis Protein Metabolic Process Skeletal System Development Endodermal Cell Differentiation Ossification Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Axon Guidance Embryo Implantation Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Endoderm Development Nervous System Development Locomotion Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Axonogenesis Response To Amino Acid Synaptic Growth At Neuromuscular Junction Axon Development Cell Recognition Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Collateral Sprouting In Absence Of Injury Neuron Projection Morphogenesis Regulation Of Protein Binding Regulation Of Locomotion Regulation Of Cellular Component Movement Organ Development Positive Regulation Of Receptor Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Neurogenesis Cell Morphogenesis Involved In Differentiation Cellular Response To Acid Chemical Glycosaminoglycan Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification
Tagcloud ?		aabs ac adenocarcinoma antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us
Tagcloud (Difference) ?		aabs ac adenocarcinoma antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us
Tagcloud (Intersection) ?