HAPLN1 and MMP10

Number of citations of the paper that reports this interaction (PubMedID 7694569)
30

Data Source:
HPRD (in vitro)

		HAPLN1	MMP10
Description		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 10
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Synapse Perineuronal Net	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process
Pathways		ECM proteoglycans	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Hyaluronic acid	Marimastat N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Blood protein levels ( 30072576) Carotid intima media thickness (mean) ( 31801372) Diisocyanate-induced asthma ( 25918132) Gastroesophageal reflux disease ( 31527586) Metabolite levels ( 23823483) Prostate cancer ( 17903305) Visceral fat ( 22589738) Waist circumference ( 28552196) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)	Blood protein levels ( 30072576) Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	3 interacting genes: BCAN HAPLN1 MMP9
Entrez ID		1404	4319
HPRD ID		00275	01704
Ensembl ID		ENSG00000145681	ENSG00000166670
Uniprot IDs		P10915	P09238
PDB IDs			1Q3A 3V96 4ILW
Enriched GO Terms of Interacting Partners?		Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Endopeptidase Activity Metalloendopeptidase Activity Metallopeptidase Activity Extracellular Space Serine-type Endopeptidase Activity Cellular Response To UV-A Response To Amyloid-beta Response To UV-A Extracellular Region Peptidase Activity Proteolysis Cellular Response To UV Response To Light Stimulus Perineuronal Net Golgi Lumen Cellular Response To Light Stimulus Extracellular Matrix Structural Constituent Conferring Compression Resistance Protein Metabolic Process Regulation Of Cell Migration Response To Radiation Central Nervous System Development Regulation Of Cell Motility Response To UV Regulation Of Locomotion Hyaluronic Acid Binding Cellular Response To Radiation Skeletal System Development Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Metal Ion Binding Endodermal Cell Differentiation Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Ephrin Receptor Signaling Pathway Hydrolase Activity Cellular Response To Oxygen-containing Compound Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding	Perineuronal Net Central Nervous System Development Skeletal System Development Hyaluronic Acid Binding System Development Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Extracellular Matrix Cellular Response To UV Cellular Response To Light Stimulus Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Mitochondrion Organization Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Glucose Catabolic Process To Lactate Via Pyruvate Germ Cell Nucleus Cellular Response To Actinomycin D Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Positive Regulation Of Thymocyte Apoptotic Process Response To Actinomycin D T Cell Proliferation Involved In Immune Response Histone Deacetylase Regulator Activity Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of G1 To G0 Transition Glial Cell Apoptotic Process Cellular Response To UV-C ATP-dependent DNA/DNA Annealing Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Mononuclear Cell Differentiation Response To Light Stimulus Cellular Response To UV-A Extracellular Space TFIID-class Transcription Factor Complex Binding Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Antibiotic Extracellular Matrix Structural Constituent Conferring Compression Resistance
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