HAPLN1 and MMP10

Number of citations of the paper that reports this interaction (PMID 7694569)
9

Data Source:
HPRD (in vitro)

		HAPLN1	MMP10
Gene Name		hyaluronan and proteoglycan link protein 1	matrix metallopeptidase 10 (stromelysin 2)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding	Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Cell Adhesion Central Nervous System Development Extracellular Matrix Organization	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process
Pathways		ECM proteoglycans	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 22138694) Prostate cancer ( 17903305) Visceral fat ( 22589738)	Multiple sclerosis ( 23412934) Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: ACAN APP MMP10 MMP2 MMP3 MMP7 MMP9 VCAN	3 interactors: BCAN HAPLN1 MMP9
Entrez ID		1404	4319
HPRD ID		00275	01704
Ensembl ID		ENSG00000145681	ENSG00000166670
Uniprot IDs		P10915	P09238
PDB IDs			1Q3A 3V96
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Catabolic Process Proteolysis Protein Metabolic Process Skeletal System Development Endodermal Cell Differentiation Ossification Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Axon Guidance Embryo Implantation Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Endoderm Development Nervous System Development Locomotion Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Axonogenesis Response To Amino Acid Synaptic Growth At Neuromuscular Junction Axon Development Cell Recognition Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Formation Of Primary Germ Layer Movement Of Cell Or Subcellular Component Regulation Of Cell Motility Collateral Sprouting In Absence Of Injury Neuron Projection Morphogenesis Regulation Of Protein Binding Regulation Of Locomotion Regulation Of Cellular Component Movement Organ Development Positive Regulation Of Receptor Binding Negative Regulation Of Hydrogen Peroxide Metabolic Process Neurogenesis Cell Morphogenesis Involved In Differentiation Cellular Response To Acid Chemical Glycosaminoglycan Metabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Skeletal System Development Extracellular Matrix Disassembly Positive Regulation Of Receptor Binding Positive Regulation Of Keratinocyte Migration Nervous System Development Dermatan Sulfate Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Negative Regulation Of Cation Channel Activity Macrophage Differentiation Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Endodermal Cell Differentiation Central Nervous System Development Negative Regulation Of Transporter Activity System Development Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Endoderm Formation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cell Adhesion Chondroitin Sulfate Metabolic Process Collagen Catabolic Process Multicellular Organismal Development Positive Regulation Of Protein Binding Hippocampus Development Anatomical Structure Development Regulation Of Cation Channel Activity Embryo Implantation Collagen Metabolic Process Positive Regulation Of Epithelial Cell Migration Multicellular Organismal Macromolecule Metabolic Process Endoderm Development Multicellular Organismal Metabolic Process Negative Regulation Of Ion Transport Limbic System Development Ephrin Receptor Signaling Pathway Glycosaminoglycan Biosynthetic Process Developmental Process Proteoglycan Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of Binding Catabolic Process Formation Of Primary Germ Layer Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration
Tagcloud ?		aabs ac adenocarcinoma antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Difference) ?		aabs ac adenocarcinoma antigens autoantibodies autoantigens autologous bigh3 coincidently comparative comprised consists dimensional discover expressions hyaluronan ig immunoblotting immunostaining link proteoglycan sera sero spots stroma surrounding thirty transforming tumor	affecting bad biochemical blotting cadherin compartments concomitant conveys cxcr4 delay elisa extracellular herein invasion jnk matrix mcf7 mek obtain overexpressing ras reporter semi sirna snail sp1 stats tlmp2 valuable
Tagcloud (Intersection) ?