VPS37A and TSG101

Number of citations of the paper that reports this interaction (PMID 15218037)
49

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		VPS37A	TSG101
Gene Name		vacuolar protein sorting 37 homolog A (S. cerevisiae)	tumor susceptibility 101
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Cytoplasm Centrosome Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle	ESCRT I Complex Nucleolus Cytoplasm Early Endosome Late Endosome Multivesicular Body Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function		DNA Binding Transcription Corepressor Activity Protein Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Calcium-dependent Protein Binding
	Biological Process	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Intracellular Transport Of Virus	Regulation Of Cell Growth Cellular Protein Modification Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Keratinocyte Differentiation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Transcription, DNA-templated Viral Budding Cell Division Membrane Organization Intracellular Transport Of Virus Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Vesicular Exosome Assembly
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Tonometry ( 17903302)
Protein-Protein Interactions		6 interactors: APP HGS KDM1A TRIM42 TSG101 VPS28	69 interactors: AATF ADRB2 AKAP9 AR ARRDC1 BCR BIRC2 CDKN1A CDS2 CEP55 DAXX DMAP1 DNMT1 DZIP3 EP300 FAM9B GGA1 GGA3 GMCL1 HAUS1 HCK HCRP1 HGS IQGAP1 ITSN1 JUN KIF5A KIFC3 KRT13 KRT15 KRT31 LRSAM1 MDM2 MGRN1 MKRN3 MVB12A NR3C1 PDCD6IP PDLIM7 PPFIBP2 RAD18 RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCNN1A SNF8 SYCE1 TAX1BP1 THRB TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM74 UBA52 UBAP1 USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D
Entrez ID		137492	7251
HPRD ID		13410	03229
Ensembl ID		ENSG00000155975	ENSG00000074319
Uniprot IDs		Q8NEZ2	Q99816
PDB IDs			1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Endosomal Transport Protein Targeting To Vacuole Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Positive Regulation Of Exocytosis Intracellular Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Establishment Of Localization In Cell Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Exocytosis Membrane Organization Negative Regulation Of Protein Metabolic Process Cellular Localization Collateral Sprouting In Absence Of Injury Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Life Cycle Collateral Sprouting Axon Midline Choice Point Recognition Protein Processing Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway Axon Choice Point Recognition Late Endosome To Vacuole Transport Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Viral Budding Positive Regulation Of Secretion Neuron Remodeling Protein Transport Gene Expression Positive Regulation Of Megakaryocyte Differentiation Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Regulation Of Cell Proliferation Regulation Of Vesicle-mediated Transport	Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Endosomal Transport Establishment Of Protein Localization Intracellular Transport Of Virus Viral Process Protein Transport Protein Localization Protein Catabolic Process Intracellular Transport Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Establishment Of Localization In Cell Viral Life Cycle Protein Ubiquitination Apoptotic Process Cellular Localization Protein Modification By Small Protein Conjugation Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Cell Death Enzyme Linked Receptor Protein Signaling Pathway Modification-dependent Protein Catabolic Process Death Protein Polyubiquitination Cellular Macromolecule Catabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Membrane Organization Apoptotic Signaling Pathway Transport Positive Regulation Of Metabolic Process Cellular Response To Organic Substance Response To Organic Substance Regulation Of Protein Metabolic Process Vacuolar Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Apoptotic Process Protein Processing Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Cell Death Response To Lipid Signal Transduction By P53 Class Mediator
Tagcloud ?		acidic alpha2 alpha2beta1 biogenesis bodies clustering dil downregulation echovirus endosomal endosomes enveloped escrts ev1 integrin internalization internalized lbpa live lysosomal lysosomes multivesicular mvbs picornavirus separate tsg101 vesicles vps24 vps4	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Difference) ?		acidic alpha2 alpha2beta1 biogenesis bodies clustering dil downregulation echovirus endosomal endosomes enveloped escrts ev1 integrin internalization internalized lbpa live lysosomal lysosomes multivesicular mvbs picornavirus separate vesicles vps24 vps4	000xg calreticulin cd81 centrifugation cleared contaminating devoid dulbecco eagle exosomal exosome exosomes fill fl3 hek293 impacted microsomes nanoparticle nta overnight pelleted phenol purity sedimentation speeds syntenin ultracentrifugation vdac1 vesicle
Tagcloud (Intersection) ?		tsg101