VPS37A and VPS28

Number of citations of the paper that reports this interaction (PMID 15240819)
34

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		VPS37A	VPS28
Gene Name		vacuolar protein sorting 37 homolog A (S. cerevisiae)	vacuolar protein sorting 28 homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Cytoplasm Centrosome Endosome Membrane Late Endosome Membrane Intracellular Membrane-bounded Organelle	ESCRT I Complex Cytoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Late Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function		Protein Binding Protein Complex Binding
	Biological Process	Protein Transport Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Intracellular Transport Of Virus	Viral Process Endosomal Transport Viral Life Cycle Virion Assembly Viral Protein Processing Negative Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Intracellular Transport Of Virus
Pathways		Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle	Assembly Of The HIV Virion Synthesis And Processing Of GAG, GAGPOL Polyproteins HIV Life Cycle Budding and maturation of HIV virion HIV Infection Endosomal Sorting Complex Required For Transport (ESCRT) Membrane binding and targetting of GAG proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Tonometry ( 17903302)
Protein-Protein Interactions		6 interactors: APP HGS KDM1A TRIM42 TSG101 VPS28	27 interactors: ASF1A BLZF1 CARD9 CBX5 FABP3 FAM154A GABARAP GLCCI1 GOLGA2 INCA1 MBIP PDCD6IP PNMA5 RASSF5 SKIL SMN2 TCF12 TCF4 TRIM27 TRIM54 TSG101 UBA52 USHBP1 VPS37A VPS37B VPS37C VPS52
Entrez ID		137492	51160
HPRD ID		13410	11675
Ensembl ID		ENSG00000155975	ENSG00000160948
Uniprot IDs		Q8NEZ2	Q548N1 Q9UK41
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Protein Processing Endosomal Transport Protein Targeting To Vacuole Virion Assembly Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Intracellular Transport Of Virus Positive Regulation Of Exocytosis Intracellular Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vacuolar Transport Regulation Of ERBB Signaling Pathway Regulation Of Primitive Erythrocyte Differentiation Establishment Of Localization In Cell Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Binding Negative Regulation Of Cellular Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Regulation Of Exocytosis Membrane Organization Negative Regulation Of Protein Metabolic Process Cellular Localization Collateral Sprouting In Absence Of Injury Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Life Cycle Collateral Sprouting Axon Midline Choice Point Recognition Protein Processing Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Endosome Transport Via Multivesicular Body Sorting Pathway Axon Choice Point Recognition Late Endosome To Vacuole Transport Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Histone H3-K4 Demethylation Viral Budding Positive Regulation Of Secretion Neuron Remodeling Protein Transport Gene Expression Positive Regulation Of Megakaryocyte Differentiation Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Regulation Of Cell Proliferation Regulation Of Vesicle-mediated Transport	Virion Assembly Viral Protein Processing Intracellular Transport Of Virus Viral Life Cycle Protein Transport Endosomal Transport Establishment Of Protein Localization Viral Process Protein Localization Membrane Organization Protein Processing Intracellular Transport Regulation Of Extracellular Vesicular Exosome Assembly Viral Budding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Negative Regulation Of Cell Cycle Establishment Of Localization In Cell Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Gene Expression Negative Regulation Of Transferase Activity Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Cellular Localization Cell Cycle Arrest Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Protein Trimerization Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Embryonic Digestive Tract Development Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Protein Kinase Activity DNA-templated Transcription, Initiation Transport Negative Regulation Of Gene Expression Muscle Structure Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Kinase Activity Cell Cycle Positive Regulation Of Lipid Biosynthetic Process Glycogen Metabolic Process
Tagcloud ?		acidic alpha2 alpha2beta1 biogenesis bodies clustering dil downregulation echovirus endosomal endosomes enveloped escrts ev1 integrin internalization internalized lbpa live lysosomal lysosomes multivesicular mvbs picornavirus separate tsg101 vesicles vps24 vps4	advancement cd connected counterscreen crohn encodes endosomal immortalized initiating irrespective multidomain nod2 proinflammatory regulators relapsing resource revealing reveals screen secretion sensor sorting strongest subnetworks tnfalpha usp8 validate valuable vesicle
Tagcloud (Difference) ?		acidic alpha2 alpha2beta1 biogenesis bodies clustering dil downregulation echovirus endosomes enveloped escrts ev1 integrin internalization internalized lbpa live lysosomal lysosomes multivesicular mvbs picornavirus separate tsg101 vesicles vps24 vps4	advancement cd connected counterscreen crohn encodes immortalized initiating irrespective multidomain nod2 proinflammatory regulators relapsing resource revealing reveals screen secretion sensor sorting strongest subnetworks tnfalpha usp8 validate valuable vesicle
Tagcloud (Intersection) ?		endosomal