VPS37A and TRIM42

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		VPS37A	TRIM42
Description		VPS37A subunit of ESCRT-I	tripartite motif containing 42
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Nucleoplasm Endosome Centrosome Cytosol Endosome Membrane Membrane Late Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Targeting To Membrane Protein Targeting To Vacuole Protein Transport Macroautophagy Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Fission	Protein Ubiquitination
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Schizophrenia ( 28991256) Tonometry ( 17903302)	Bipolar disorder (body mass index interaction) ( 24322204) Refractive astigmatism ( 25367360)
Interacting Genes		9 interacting genes: APP HGS KDM1A TRIM42 TRIM55 TRIM63 TSG101 UBC VPS28	147 interacting genes: ADAMTSL4 AIRIM AQP1 ARMC7 ARNT2 ARRDC3 ATG9A AXIN1 BACH2 BEX2 CARD9 CATSPER1 CBY2 CCDC120 CCDC24 CCDC33 CDCA7L CEP70 CERK CHCHD2 CHRD CREB5 CYSRT1 EFEMP2 EFHC2 EMD FAM124B FAM90A1 FBLN1 FCHO1 FNDC3B GLI1 GLRX3 GLYCTK GNE GOLGA2 GUCD1 HOXA1 HOXC8 HSD3B7 IGFN1 IHO1 IKZF3 IL16 IQUB KCTD9 KLHL38 KPRP KRT13 KRT15 KRT34 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP3-2 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-6 KRTAP5-7 KRTAP9-3 L3MBTL2 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LONRF1 LZTS2 MAGOHB MAPKBP1 MEIS2 MEOX2 MFAP1 MGAT5B MID2 MTUS2 MVP NBPF19 NEK8 NOTCH2NLA NUFIP2 OTX1 PCSK5 PHLDA1 PLSCR1 PLSCR4 PNMA1 POU4F2 PRKAB2 PROP1 PSMA1 PSMD9 PTGER3 R3HDM2 RAMAC RCOR3 RUNX1T1 SCNM1 SHFL SLIT1 SMARCC1 SMCP SPAG8 SSX2IP STK16 TASOR2 TCAF1 TFAP2D TLX3 TMEM150A TRAF1 TRAF2 TRAPPC2B TRIM23 TRIM27 TXNDC5 VGLL3 VPS37A VWC2L YIPF3 YWHAQ YY1 ZBTB1 ZNF330 ZNF414
Entrez ID		137492	287015
HPRD ID		13410	15559
Ensembl ID		ENSG00000155975	ENSG00000155890
Uniprot IDs		Q8NEZ2	Q8IWZ5
PDB IDs		8E22
Enriched GO Terms of Interacting Partners?		Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of Ubiquitin-dependent Endocytosis Multivesicular Body Organization Multivesicular Body Assembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway Establishment Of Protein Localization To Vacuole Protein Metabolic Process Endosome Organization Protein Localization To Vacuole ESCRT I Complex Early Endosome Ubiquitin Binding Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Viral Budding Via Host ESCRT Complex Positive Regulation Of Endocytosis Macroautophagy Viral Budding Vacuolar Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Neuron Maturation Regulation Of Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Early Endosome Membrane Protein Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Transport Macromolecule Metabolic Process Endosomal Transport Protein Modification By Small Protein Conjugation Regulation Of Glycolytic Process Endosome Membrane Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Establishment Of Protein Localization Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Endosome Amylin Binding Regulation Of Protein Metabolic Process Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Endocytosis Vesicle Organization Autophagy	Intermediate Filament Keratin Filament Epidermis Development Keratinization Protein Binding Tissue Development Identical Protein Binding CD4 Receptor Binding Hair Cycle
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