CPE and CHD3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CPE	CHD3
Gene Name		carboxypeptidase E	chromodomain helicase DNA binding protein 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex Intermediate Filament Cytoskeleton
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Proteolysis Neuropeptide Signaling Pathway Metabolic Process Insulin Processing Cellular Protein Metabolic Process Protein Localization To Membrane	Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spindle Organization Chromatin Modification DNA Duplex Unwinding Centrosome Organization
Pathways		Peptide hormone metabolism Insulin processing	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs		Insulin Regular Insulin, porcine
Diseases
GWAS
Protein-Protein Interactions		17 interactors: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	90 interactors: ACTR1B ADH5 AIMP2 ATPIF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CSTF2 CTBP1 CTTN FABP4 FAM134A FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SDCCAG3 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBE2I UROD VIM XRCC4 YAE1D1 ZHX1
Entrez ID		1363	1107
HPRD ID		00272	09071
Ensembl ID		ENSG00000109472	ENSG00000170004
Uniprot IDs		P16870	B3KWV4 Q12873 Q2TAZ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Feeding Behavior Negative Regulation Of Feeding Behavior Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Behavior Regulation Of Feeding Behavior Positive Regulation Of Hormone Secretion Telomere Maintenance Via Semi-conservative Replication G-protein Coupled Receptor Signaling Pathway Nuclear DNA Replication Telomere Maintenance Via Recombination Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Oligomerization Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Eating Behavior DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Glucose Metabolic Process Regulation Of Behavior Behavioral Fear Response Neuron Recognition Positive Regulation Of Protein Secretion Regulation Of Cellular Ketone Metabolic Process Regulation Of Insulin Secretion Fear Response Response To Hormone Regulation Of Peptide Hormone Secretion Regulation Of Gluconeogenesis Cellular Response To Hormone Stimulus Response To Anesthetic Response To Fluoxetine Response To L-glutamate Regulation Of Hormone Secretion Regulation Of Synapse Assembly Positive Regulation Of Insulin Secretion Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Telomere Maintenance Positive Regulation Of Secretion Negative Regulation Of Glycogen Catabolic Process Negative Regulation Of Negative Chemotaxis Positive Regulation Of Protein Transport Multicellular Organismal Response To Stress Regulation Of Synapse Organization Regulation Of Synapse Structure Or Activity Taste Bud Development Apoptotic Process Involved In Luteolysis Dendrite Extension	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Biosynthetic Process Protein Sumoylation Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Cellular Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death B Cell Activation Cellular Process Negative Regulation Of Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Death Programmed Cell Death Cell Differentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Negative Regulation Of Apoptotic Process Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process
Tagcloud ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion	ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Difference) ?		attenuating chimera chimeras cytopathic flanked glycoproteins hamsters hemagglutinin hn illustrated lies llc measles neuraminidase noncytopathic nontranslated noteworthy parainfluenza parent piv1 piv2 piv3 presumed replicates resembles rpiv3 somatitis staged virion	ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Intersection) ?