CPE and NTS

Number of citations of the paper that reports this interaction (PubMedID 8770919)
0

Data Source:
HPRD (in vivo)

		CPE	NTS
Description		carboxypeptidase E	neurotensin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Endomembrane System Membrane Transport Vesicle Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome	Extracellular Region Transport Vesicle Cytoplasmic Vesicle Axon Terminus
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Neurexin Family Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Neuropeptide Receptor Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Proteolysis Peptide Metabolic Process Cell Communication Neuropeptide Signaling Pathway Intracellular Protein Localization Wnt Signaling Pathway Protein Processing Signaling Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Modification Process Protein Localization To Membrane	Signal Transduction Neuropeptide Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Killing Of Cells Of Another Organism Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Blood Vessel Diameter Maintenance
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Insulin human
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	10 interacting genes: ACE2 ARRB2 CPE MEP1A MFF NLN NTSR1 NTSR2 PREP SORT1
Entrez ID		1363	4922
HPRD ID		00272	08878
Ensembl ID		ENSG00000109472	ENSG00000133636
Uniprot IDs		A0A384N679 P16870	P30990 Q6FH20
PDB IDs			2LNE 2LNF 2LNG 2LYW 2OYV 2OYW 3F6K 4PO7 5LUZ 6UP7 8VJY
Enriched GO Terms of Interacting Partners?		Hormone Activity Feeding Behavior Receptor Ligand Activity Axolemma G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cell Junction Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Hormone Activity Eating Behavior Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Extracellular Region Positive Regulation Of Glucose Metabolic Process Regulation Of Peptide Hormone Secretion Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Neuron Recognition Thyrotropin-releasing Hormone Activity	Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Neuropeptide Signaling Pathway Metallocarboxypeptidase Activity G Protein-coupled Neurotensin Receptor Activity Metallopeptidase Activity Hormone Metabolic Process Peptidase Activity Protein Processing Proteolysis Protein Maturation Angiotensin Maturation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Carboxypeptidase Activity Regulation Of Biological Quality Regulation Of Hormone Levels Import Into Cell Peptide Metabolic Process Neurotensin Receptor Activity, Non-G Protein-coupled Plasma Membrane Endocytic Vesicle Membrane Angiotensin Receptor Binding Clathrin-coated Pit Adult Locomotory Behavior Cytoplasmic Vesicle Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Inositol Phosphate Catabolic Process Regulation Of Amine Transport Oligopeptidase Activity Nerve Growth Factor Receptor Activity Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Peptidyl-dipeptidase Activity Regulation Of Striated Muscle Cell Differentiation Hydrolase Activity Metalloendopeptidase Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Membrane Potential Membrane Protein Localization To Secretory Granule Positive Regulation Of Gamma-aminobutyric Acid Secretion Entry Receptor-mediated Virion Attachment To Host Cell Endocytosis Amino Acid Transport Symmetric Synapse Regulation Of Skeletal Muscle Fiber Differentiation Viral Translation Viral Life Cycle
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