CPE and CCK

Number of citations of the paper that reports this interaction (PubMedID 9275097)
0

Data Source:
HPRD (in vivo)

		CPE	CCK
Description		carboxypeptidase E	cholecystokinin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Endomembrane System Membrane Transport Vesicle Secretory Granule Transport Vesicle Membrane Secretory Granule Membrane Cytoplasmic Vesicle Extracellular Exosome	Extracellular Region Extracellular Space Axon
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Neurexin Family Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding	Hormone Activity Neuropeptide Hormone Activity Protein Binding Receptor Ligand Activity Peptide Hormone Receptor Binding
	Biological Process	Cardiac Left Ventricle Morphogenesis Proteolysis Peptide Metabolic Process Cell Communication Neuropeptide Signaling Pathway Intracellular Protein Localization Wnt Signaling Pathway Protein Processing Signaling Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Modification Process Protein Localization To Membrane	Neuron Migration Signal Transduction Axonogenesis Digestion Cholecystokinin Signaling Pathway Eating Behavior
Pathways		Insulin processing	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Insulin human	Camostat
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adult body size ( 32376654) Body mass index ( 24348519 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body size at age 10 ( 32376654) Night sleep phenotypes ( 27126917)
Interacting Genes		18 interacting genes: BDNF CCK CHD3 CNTNAP2 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	7 interacting genes: CCKAR CCKBR CPE ENPEP MEP1A MEP1B UBQLN2
Entrez ID		1363	885
HPRD ID		00272	00321
Ensembl ID		ENSG00000109472	ENSG00000187094
Uniprot IDs		A0A384N679 P16870	P06307 Q6FG82
PDB IDs			7EZH 7EZK 7EZM 7MBX 7MBY 7XOU 8IA7 9BKJ 9BKK
Enriched GO Terms of Interacting Partners?		Hormone Activity Feeding Behavior Receptor Ligand Activity Axolemma G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cell Junction Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Neuropeptide Hormone Activity Eating Behavior Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Extracellular Region Positive Regulation Of Glucose Metabolic Process Regulation Of Peptide Hormone Secretion Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Neuron Recognition Thyrotropin-releasing Hormone Activity	Cholecystokinin Receptor Activity Metallopeptidase Activity Meprin A Complex Cholecystokinin Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Peptidase Activity Regulation Of Hormone Levels Proteolysis Protein Processing Hormone Metabolic Process Plasma Membrane Peptide Hormone Binding Protein Maturation Peptide Metabolic Process Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Glutamyl Aminopeptidase Activity Metalloendopeptidase Activity Neuropeptide Signaling Pathway Epidermal Growth Factor Receptor Ligand Maturation Negative Regulation Of G Protein-coupled Receptor Internalization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Localization To Secretory Granule Regulation Of Biological Quality Membrane Extracellular Space Negative Regulation Of Clathrin-dependent Endocytosis Hydrolase Activity Protein Metabolic Process 1-phosphatidylinositol-3-kinase Regulator Activity G Protein-coupled Receptor Signaling Pathway PH Reduction Gastric Acid Secretion Metallodipeptidase Activity Insulin Processing Cytoplasmic Vesicle Zinc Ion Binding Cardiac Left Ventricle Morphogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Angiotensin Maturation Neurexin Family Protein Binding Glomerulus Development Negative Regulation Of Receptor Internalization Insulin Metabolic Process Peptide Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Neuropeptide Receptor Activity G Protein-coupled Receptor Activity
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