ADORA2B and NHERF2

Number of citations: 0 (PubMedID 12080047)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		ADORA2B	NHERF2
Name		adenosine A2b receptor	NHERF family PDZ scaffold protein 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Vasodilation Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Associated Smooth Muscle Presynaptic Modulation Of Chemical Synaptic Transmission	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	None
Drugs		Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883	None
GWAS		HDL cholesterol levels in HIV infection ( 33109212 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 )	No GWAS studies recorded
Interacting Genes		7 interacting genes: ADA DCC EZR NHERF2 NTN1 TPD52L2 ZNF267	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		136	9351
HPRD ID		15971	05946
Ensembl ID		ENSG00000170425	ENSG00000065054
Uniprot IDs		P29275	H3BQS0 Q15599
PDB IDs		7XY6 7XY7 8HDO 8HDP	2D11 2HE4 2OCS 4P0C
GO Terms Enriched among Interactors		Anterior/posterior Axon Guidance Positive Regulation Of Germinal Center Formation Response To Purine-containing Compound Negative Regulation Of Mucus Secretion Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Inosine Biosynthetic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Penile Erection Negative Regulation Of Multicellular Organismal Process Hypoxanthine Metabolic Process Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Lumen Hypoxanthine Salvage Mature B Cell Apoptotic Process Cell Adhesion Negative Regulation Of Adenosine Receptor Signaling Pathway Adenosine Catabolic Process 2'-deoxyadenosine Deaminase Activity DATP Catabolic Process DAMP Catabolic Process Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Hypoxanthine Biosynthetic Process Cell-cell Adhesion Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Nervous System Development Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Neuron Migration Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Cdc42 Protein Signal Transduction Axonogenesis Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis