ADORA2B and NTN1

Number of citations of the paper that reports this interaction (PMID 11048721)
33

Data Source:
HPRD (in vivo, in vitro)

		ADORA2B	NTN1
Gene Name		adenosine A2b receptor	netrin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	G-protein Coupled Adenosine Receptor Activity	Protein Binding
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Smooth Muscle	Neuron Migration Apoptotic Process Axon Guidance Positive Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Regulation Of Cell Migration Negative Regulation Of Axon Extension Anterior/posterior Axon Guidance Establishment Of Nucleus Localization Inner Ear Morphogenesis Positive Regulation Of Axon Extension Mammary Gland Duct Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	DSCAM interactions Axon guidance Role of second messengers in netrin-1 signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin-1 signaling
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Breast cancer (prognosis) ( 23319801)
Protein-Protein Interactions		7 interactors: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	5 interactors: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		136	9423
HPRD ID		15971	03368
Ensembl ID		ENSG00000170425	ENSG00000065320
Uniprot IDs		P29275	O95631
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Axon Guidance Negative Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Single Organismal Cell-cell Adhesion Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Projection Development Chemotaxis Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuron Projection Morphogenesis Regulation Of Cell Size Negative Regulation Of Cell Projection Organization Netrin-activated Signaling Pathway Spinal Cord Ventral Commissure Morphogenesis Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Differentiation Regulation Of Axonogenesis Response To External Stimulus Neuron Migration Dorsal/ventral Axon Guidance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Differentiation Membrane To Membrane Docking Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Positive Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Neuron Development	Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Response To External Stimulus Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cell Development Positive Regulation Of Cell Death Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Nervous System Development Anatomical Structure Morphogenesis Spinal Cord Ventral Commissure Morphogenesis Apoptotic Process Programmed Cell Death Dorsal/ventral Axon Guidance Cell Death Death Negative Regulation Of Collateral Sprouting Positive Regulation Of Chronic Inflammatory Response Relaxation Of Vascular Smooth Muscle Cell Differentiation Apoptotic Signaling Pathway Relaxation Of Smooth Muscle Regulation Of Apoptotic Process Positive Regulation Of Guanylate Cyclase Activity Regulation Of Cell Death Positive Regulation Of Mast Cell Degranulation Regulation Of Chronic Inflammatory Response Adenosine Receptor Signaling Pathway Positive Regulation Of Mast Cell Activation Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Dendrite Development Positive Regulation Of MAPK Cascade
Tagcloud ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 polyp signatures slc9a2 vwf
Tagcloud (Difference) ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological	actg2 adenomatous archived b4ganlt2 bank casp3 cdx1 cdx2 classifier cnn1 col1a1 custom ezr fsp1 genomelab hcellmarkerplex house hybridisation incorporates krt18 lgr5 ms4a12 muc2 mucin nox1 polyp signatures slc9a2 vwf
Tagcloud (Intersection) ?