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ADORA2B and NTN1
Number of citations of the paper that reports this interaction (PubMedID
11048721
)
0
Data Source:
HPRD
(in vitro, in vivo)
ADORA2B
NTN1
Description
adenosine A2b receptor
netrin 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Extracellular Region
Basement Membrane
Nucleoplasm
Cytoplasm
Cytosol
Actin Cytoskeleton
Synapse
Glutamatergic Synapse
Molecular Function
G Protein-coupled Adenosine Receptor Activity
G Protein-coupled Receptor Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Protein Binding
Biological Process
G Protein-coupled Adenosine Receptor Signaling Pathway
Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of CGMP-mediated Signaling
CGMP-mediated Signaling
Positive Regulation Of Chemokine Production
Positive Regulation Of Interleukin-6 Production
Vasodilation
Mast Cell Degranulation
Positive Regulation Of Mast Cell Degranulation
Relaxation Of Vascular Associated Smooth Muscle
Presynaptic Modulation Of Chemical Synaptic Transmission
Neuron Migration
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Substrate-dependent Cell Migration, Cell Extension
Nuclear Migration
Ras Protein Signal Transduction
Axonogenesis
Axon Guidance
Cell Population Proliferation
Glial Cell Proliferation
Regulation Of Cell Migration
Negative Regulation Of Axon Extension
Mammary Gland Development
Cdc42 Protein Signal Transduction
Anterior/posterior Axon Guidance
Inner Ear Morphogenesis
Positive Regulation Of Axon Extension
Regulation Of Synapse Assembly
Positive Regulation Of Glial Cell Proliferation
Mammary Gland Duct Morphogenesis
Chemorepulsion Of Axon
Motor Neuron Migration
Cell-cell Adhesion
Regulation Of Glial Cell Migration
Positive Regulation Of Cell Motility
Pathways
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
ADORA2B mediated anti-inflammatory cytokines production
Netrin-1 signaling
Netrin-1 signaling
DSCAM interactions
DCC mediated attractive signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
Netrin mediated repulsion signals
Role of second messengers in netrin-1 signaling
Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Caffeine
Theophylline
Adenosine
Enprofylline
Defibrotide
CVT-6883
Diseases
GWAS
HDL cholesterol levels in HIV infection (
33109212
)
Immune reponse to smallpox (secreted IL-12p40) (
22610502
)
Appendicular lean mass (
33097823
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Breast cancer (prognosis) (
23319801
)
Cortex volume (
31530798
)
Feeling hurt (
29500382
)
Heel bone mineral density (
28869591
30598549
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Nonsyndromic cleft lip with or without cleft palate (
25775280
33898419
)
Orofacial clefts (
33137956
)
Percentage gas trapping (
26030696
)
Rostral middle frontal gyrus volume (
31530798
)
Total grey matter volume (
31530798
)
Interacting Genes
7 interacting genes:
ADA
DCC
EZR
NHERF2
NTN1
TPD52L2
ZNF267
5 interacting genes:
ADORA2B
DCC
NEO1
UNC5A
UNC5C
Entrez ID
136
9423
HPRD ID
15971
03368
Ensembl ID
ENSG00000170425
ENSG00000065320
Uniprot IDs
P29275
O95631
PDB IDs
7XY6
7XY7
8HDO
8HDP
4URT
6FKQ
7NDG
7NE0
7NE1
Enriched GO Terms of Interacting Partners
?
Anterior/posterior Axon Guidance
Positive Regulation Of Germinal Center Formation
Response To Purine-containing Compound
Negative Regulation Of Mucus Secretion
Negative Regulation Of Mature B Cell Apoptotic Process
Regulation Of T Cell Receptor Signaling Pathway
Inosine Biosynthetic Process
DATP Metabolic Process
Deoxyadenosine Catabolic Process
Purine Deoxyribonucleoside Triphosphate Catabolic Process
Penile Erection
Negative Regulation Of Multicellular Organismal Process
Hypoxanthine Metabolic Process
Regulation Of Anatomical Structure Morphogenesis
Cytoplasmic Vesicle Lumen
Hypoxanthine Salvage
Mature B Cell Apoptotic Process
Cell Adhesion
Negative Regulation Of Adenosine Receptor Signaling Pathway
Adenosine Catabolic Process
2'-deoxyadenosine Deaminase Activity
DATP Catabolic Process
DAMP Catabolic Process
Xanthine Biosynthetic Process
Negative Regulation Of Penile Erection
Hypoxanthine Biosynthetic Process
Cell-cell Adhesion
Regulation Of Developmental Growth
Regulation Of Growth
Negative Regulation Of Nervous System Development
Regulation Of Axonogenesis
Dorsal/ventral Axon Guidance
Negative Regulation Of Axonogenesis
Negative Regulation Of Developmental Growth
Negative Regulation Of Neurogenesis
Neuron Migration
Spinal Cord Ventral Commissure Morphogenesis
Negative Regulation Of Neuron Projection Development
Intestinal Hexose Absorption
Terminal Web Assembly
Protein Localization To Cell Cortex
Intestinal D-glucose Absorption
Type 3 Metabotropic Glutamate Receptor Binding
Type 2 Metabotropic Glutamate Receptor Binding
Cdc42 Protein Signal Transduction
Axonogenesis
Purine Deoxyribonucleoside Metabolic Process
GMP Salvage
Purine Ribonucleoside Catabolic Process
Deoxyribonucleoside Triphosphate Catabolic Process
Anterior/posterior Axon Guidance
Neuron Projection Guidance
Axon Guidance
Netrin Receptor Activity
Neuron Projection Development
Netrin-activated Signaling Pathway
Plasma Membrane Bounded Cell Projection Organization
Cell Projection Organization
Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus
Modulation Of Chemical Synaptic Transmission
Netrin Receptor Activity Involved In Chemorepulsion
Schaffer Collateral - CA1 Synapse
Postsynaptic Density Membrane
Cell Surface
Negative Regulation Of Neuron Projection Development
Growth Cone
Neuron Migration
Dorsal/ventral Axon Guidance
Spinal Cord Ventral Commissure Morphogenesis
Neuron Projection Membrane
Negative Regulation Of Cell Projection Organization
Positive Regulation Of Chronic Inflammatory Response
G Protein-coupled Adenosine Receptor Activity
Plasma Membrane
Cell Death
Apoptotic Process
Programmed Cell Death
Dorsal Root Ganglion Development
Relaxation Of Vascular Associated Smooth Muscle
Chemorepulsion Of Axon
Positive Regulation Of CGMP-mediated Signaling
Relaxation Of Smooth Muscle
Negative Regulation Of Dendrite Development
Regulation Of Chronic Inflammatory Response
G Protein-coupled Adenosine Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Regulation Of CGMP-mediated Signaling
Negative Regulation Of Smooth Muscle Contraction
Negative Regulation Of Collateral Sprouting
Co-receptor Binding
Negative Regulation Of Axon Regeneration
BMP Receptor Binding
Negative Regulation Of Neuron Projection Regeneration
Trans-synaptic Signaling, Modulating Synaptic Transmission
Neuron Projection
Positive Regulation Of Mast Cell Degranulation
Plasma Membrane Protein Complex
Ganglion Development
Secretion By Cell
Positive Regulation Of Adenylate Cyclase Activity
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Tagcloud (Intersection)
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