ADORA2B and NTN1

Number of citations: 0 (PubMedID 11048721)
Data Source: HPRD (in vitro, in vivo)

		ADORA2B	NTN1
Name		adenosine A2b receptor	netrin 1
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Extracellular Region Basement Membrane Nucleoplasm Cytoplasm Cytosol Actin Cytoskeleton Synapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Vasodilation Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Associated Smooth Muscle Presynaptic Modulation Of Chemical Synaptic Transmission	Neuron Migration Regulation Of Transcription By RNA Polymerase II Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Axonogenesis Axon Guidance Cell Population Proliferation Glial Cell Proliferation Regulation Of Cell Migration Negative Regulation Of Axon Extension Mammary Gland Development Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Positive Regulation Of Glial Cell Proliferation Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Motor Neuron Migration Cell-cell Adhesion Regulation Of Glial Cell Migration Positive Regulation Of Cell Motility
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883	None
GWAS		HDL cholesterol levels in HIV infection ( 33109212 ) Immune reponse to smallpox (secreted IL-12p40) ( 22610502 )	Appendicular lean mass ( 33097823 ) Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer (prognosis) ( 23319801 ) Cortex volume ( 31530798 ) Feeling hurt ( 29500382 ) Heel bone mineral density ( 28869591 30598549 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419 ) Orofacial clefts ( 33137956 ) Percentage gas trapping ( 26030696 ) Rostral middle frontal gyrus volume ( 31530798 ) Total grey matter volume ( 31530798 )
Interacting Genes		7 interacting genes: ADA DCC EZR NHERF2 NTN1 TPD52L2 ZNF267	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		136	9423
HPRD ID		15971	03368
Ensembl ID		ENSG00000170425	ENSG00000065320
Uniprot IDs		P29275	O95631
PDB IDs		7XY6 7XY7 8HDO 8HDP	4URT 6FKQ 7NDG 7NE0 7NE1
GO Terms Enriched among Interactors		Anterior/posterior Axon Guidance Positive Regulation Of Germinal Center Formation Response To Purine-containing Compound Negative Regulation Of Mucus Secretion Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Inosine Biosynthetic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Penile Erection Negative Regulation Of Multicellular Organismal Process Hypoxanthine Metabolic Process Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Lumen Hypoxanthine Salvage Mature B Cell Apoptotic Process Cell Adhesion Negative Regulation Of Adenosine Receptor Signaling Pathway Adenosine Catabolic Process 2'-deoxyadenosine Deaminase Activity DATP Catabolic Process DAMP Catabolic Process Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Hypoxanthine Biosynthetic Process Cell-cell Adhesion Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Nervous System Development Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Neuron Migration Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Cdc42 Protein Signal Transduction Axonogenesis Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process	Anterior/posterior Axon Guidance Neuron Projection Guidance Axon Guidance Netrin Receptor Activity Neuron Projection Development Netrin-activated Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Modulation Of Chemical Synaptic Transmission Netrin Receptor Activity Involved In Chemorepulsion Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Cell Surface Negative Regulation Of Neuron Projection Development Growth Cone Neuron Migration Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Neuron Projection Membrane Negative Regulation Of Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Plasma Membrane Cell Death Apoptotic Process Programmed Cell Death Dorsal Root Ganglion Development Relaxation Of Vascular Associated Smooth Muscle Chemorepulsion Of Axon Positive Regulation Of CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Dendrite Development Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Collateral Sprouting Co-receptor Binding Negative Regulation Of Axon Regeneration BMP Receptor Binding Negative Regulation Of Neuron Projection Regeneration Trans-synaptic Signaling, Modulating Synaptic Transmission Neuron Projection Positive Regulation Of Mast Cell Degranulation Plasma Membrane Protein Complex Ganglion Development Secretion By Cell Positive Regulation Of Adenylate Cyclase Activity