ADORA2B

Description		adenosine A2b receptor
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GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Vasodilation Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Associated Smooth Muscle Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production
Drugs		Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883
Diseases
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)
Interacting Genes		7 interacting genes: ADA DCC EZR NHERF2 NTN1 TPD52L2 ZNF267
Entrez ID		136
HPRD ID		15971
Ensembl ID		ENSG00000170425
Uniprot IDs		P29275
PDB IDs		7XY6 7XY7 8HDO 8HDP
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Positive Regulation Of Germinal Center Formation Response To Purine-containing Compound Negative Regulation Of Mucus Secretion Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Inosine Biosynthetic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Penile Erection Negative Regulation Of Multicellular Organismal Process Hypoxanthine Metabolic Process Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Lumen Hypoxanthine Salvage Mature B Cell Apoptotic Process Cell Adhesion Negative Regulation Of Adenosine Receptor Signaling Pathway Adenosine Catabolic Process 2'-deoxyadenosine Deaminase Activity DATP Catabolic Process DAMP Catabolic Process Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Hypoxanthine Biosynthetic Process Cell-cell Adhesion Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Nervous System Development Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Neuron Migration Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Cdc42 Protein Signal Transduction Axonogenesis Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process
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