ADORA2B and TPD52L2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADORA2B	TPD52L2
Gene Name		adenosine A2b receptor	tumor protein D52-like 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Adenosine Receptor Activity	Protein Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Activation Of MAPK Activity Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cellular Defense Response G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity JNK Cascade Excretion Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Extracellular Stimulus Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Smooth Muscle	Regulation Of Cell Proliferation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Nucleotide-like (purinergic) receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Adenosine P1 receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Theophylline Adenosine Enprofylline Defibrotide
Diseases
GWAS		Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Prostate cancer ( 23535732)
Protein-Protein Interactions		7 interactors: ADA DCC EZR NTN1 SLC9A3R2 TPD52L2 ZNF267	7 interactors: ADORA2B APP MAL2 SH3GLB1 TPD52 TPD52L1 TPD52L3
Entrez ID		136	7165
HPRD ID		15971	11947
Ensembl ID		ENSG00000170425	ENSG00000101150
Uniprot IDs		P29275	O43399 Q68E05 Q6FGS1
PDB IDs
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Axon Guidance Negative Regulation Of Axonogenesis Regulation Of Cell Morphogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Adenosine Receptor Signaling Pathway Negative Regulation Of Penile Erection Deoxyadenosine Catabolic Process Xanthine Biosynthetic Process Single Organismal Cell-cell Adhesion Axonogenesis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Neuron Projection Development Chemotaxis Negative Regulation Of Mucus Secretion Purine Deoxyribonucleoside Metabolic Process Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuron Projection Morphogenesis Regulation Of Cell Size Negative Regulation Of Cell Projection Organization Netrin-activated Signaling Pathway Spinal Cord Ventral Commissure Morphogenesis Germinal Center B Cell Differentiation Adenosine Catabolic Process DATP Catabolic Process Deoxyribonucleoside Catabolic Process Inosine Biosynthetic Process Hypoxanthine Salvage Negative Regulation Of Cell Growth Cell Morphogenesis Involved In Differentiation Regulation Of Axonogenesis Response To External Stimulus Neuron Migration Dorsal/ventral Axon Guidance Hypoxanthine Metabolic Process Hypoxanthine Biosynthetic Process Negative Regulation Of Mature B Cell Apoptotic Process Neuron Projection Development Negative Regulation Of Neuron Differentiation Membrane To Membrane Docking Cell Projection Morphogenesis Positive Regulation Of Cell Differentiation Cell Part Morphogenesis Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Germinal Center Formation Positive Regulation Of Neuron Projection Development Negative Regulation Of Collateral Sprouting Neuron Development	Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Apoptotic Process Programmed Cell Death Positive Regulation Of MAP Kinase Activity Cell Death Death Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Choice Point Recognition Positive Regulation Of Chronic Inflammatory Response Regulation Of MAP Kinase Activity Regulation Of Phosphorylation Neuron Remodeling Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Regulation Of Phosphorus Metabolic Process Positive Regulation Of Guanylate Cyclase Activity Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Positive Regulation Of Mast Cell Degranulation Regulation Of Chronic Inflammatory Response Adenosine Receptor Signaling Pathway Regulation Of Peptidase Activity Positive Regulation Of Mast Cell Activation Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of MAPK Cascade Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of Protein Kinase Activity Cellular Copper Ion Homeostasis Positive Regulation Of Protein Oligomerization Positive Regulation Of CGMP Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Regulated Secretory Pathway Negative Regulation Of Muscle Contraction Relaxation Of Muscle Regulation Of CGMP Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Cellular Protein Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Transferase Activity
Tagcloud ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 trio ube2m ywhag
Tagcloud (Difference) ?		acvrl1 agtrap angpt2 angptl4 apln cbf csrp2 ednra egfl7 ero1l flowmetry flt1 hi id1 immunolabeled iodoantipyrine kdr microvasculature mins nitroarginine normoxia nos3 nudt6 perimed pf5001 prrx1 serpine1 stereological	anxa4 cacybp cfl1 ciapin1 ctro cytokinesis fam50a hspb1 incapable mefs migrated nbs ndrg ndrg1 ndrg1expression nsfl1c pcbp2 pdap1 pml proliferate proliferated relay rsu1 stations stmn1 sumo2 trio ube2m ywhag
Tagcloud (Intersection) ?