ADORA2B and DCC

Number of citations of the paper that reports this interaction (PubMedID 11048721)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ADORA2B	DCC
Description		adenosine A2b receptor	DCC netrin 1 receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse	Cytosol Plasma Membrane Cell Surface Membrane Axon Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane
	Molecular Function	G Protein-coupled Adenosine Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Vasodilation Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Relaxation Of Vascular Associated Smooth Muscle Presynaptic Modulation Of Chemical Synaptic Transmission	Neuron Migration Apoptotic Process Axonogenesis Axon Guidance Negative Regulation Of Neuron Projection Development Spinal Cord Ventral Commissure Morphogenesis Dorsal/ventral Axon Guidance Anterior/posterior Axon Guidance Negative Regulation Of Collateral Sprouting Cell-cell Adhesion Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Dendrite Development
Pathways		Adenosine P1 receptors G alpha (s) signalling events Surfactant metabolism ADORA2B mediated anti-inflammatory cytokines production	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs		Caffeine Theophylline Adenosine Enprofylline Defibrotide CVT-6883
Diseases			Colorectal cancer Cancer of the anal canal Gastric cancer
GWAS		HDL cholesterol levels in HIV infection ( 33109212) Immune reponse to smallpox (secreted IL-12p40) ( 22610502)	Age at first sexual intercourse ( 34211149 27089180) Alcoholism (alcohol use disorder factor score) ( 21529783) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Benign prostatic hyperplasia ( 30988330) Body mass index ( 28892062) Body mass index (ever vs never smoking interaction) ( 23192594) Bortezomib-induced peripheral neuropathy in multiple myeloma ( 28317148) Brain morphology (MOSTest) ( 32665545) Chronic back pain ( 30261039) Coenzyme Q10 levels ( 27149984) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Depression ( 27089181 29700475 33859377) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling miserable ( 29500382) Gallbladder cancer ( 22318345) Gastroesophageal reflux disease ( 34187846) General cognitive ability ( 29844566) General factor of neuroticism ( 30867560) Glucose homeostasis traits ( 25524916) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) Homeostasis model assessment of insulin resistance ( 33381925) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30591961) Lung function (FVC) ( 30061609 30804560) Mood instability ( 29187730 31168069) Mosquito bite size ( 28199695) Multisite chronic pain ( 33830993 31194737) Neurociticism ( 29500382) Nickel levels ( 26025379) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Putamen volume ( 29147026) Response to exercise (triglyceride level interaction) ( 26491034) Response to fenofibrate (total cholesterol levels) ( 27002377) Response to mTOR inhibitor (everolimus) ( 24009623) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 33169155 30285260) Short-term memory (digit-span task) ( 30741946) Smoking behaviour (cigarettes smoked per day) ( 27393504) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Subcortical brain region volumes ( 25607358) Survival in colorectal cancer (distant metastatic) ( 26586795) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		7 interacting genes: ADA DCC EZR NHERF2 NTN1 TPD52L2 ZNF267	28 interacting genes: ADORA2B ALDOB ANP32B APPL1 AR BARD1 CASP3 CASP9 CORO2A CTSV FBP1 HEMGN MAPK3 MAZ NCK1 NTN1 PITPNA PTK2 RASA1 RPL5 SFRP2 SIAH1 SIAH2 TBC1D2 TDRD7 TMOD1 TRMO TSTD2
Entrez ID		136	1630
HPRD ID		15971	00391
Ensembl ID		ENSG00000170425	ENSG00000187323
Uniprot IDs		P29275	P43146 Q49AK4
PDB IDs		7XY6 7XY7 8HDO 8HDP	2ED7 2ED8 2ED9 2EDB 2EDD 2EDE 3AU4 4URT 5X83
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Positive Regulation Of Germinal Center Formation Response To Purine-containing Compound Negative Regulation Of Mucus Secretion Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of T Cell Receptor Signaling Pathway Inosine Biosynthetic Process DATP Metabolic Process Deoxyadenosine Catabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process Penile Erection Negative Regulation Of Multicellular Organismal Process Hypoxanthine Metabolic Process Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Lumen Hypoxanthine Salvage Mature B Cell Apoptotic Process Cell Adhesion Negative Regulation Of Adenosine Receptor Signaling Pathway Adenosine Catabolic Process 2'-deoxyadenosine Deaminase Activity DATP Catabolic Process DAMP Catabolic Process Xanthine Biosynthetic Process Negative Regulation Of Penile Erection Hypoxanthine Biosynthetic Process Cell-cell Adhesion Regulation Of Developmental Growth Regulation Of Growth Negative Regulation Of Nervous System Development Regulation Of Axonogenesis Dorsal/ventral Axon Guidance Negative Regulation Of Axonogenesis Negative Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Neuron Migration Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Neuron Projection Development Intestinal Hexose Absorption Terminal Web Assembly Protein Localization To Cell Cortex Intestinal D-glucose Absorption Type 3 Metabotropic Glutamate Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Cdc42 Protein Signal Transduction Axonogenesis Purine Deoxyribonucleoside Metabolic Process GMP Salvage Purine Ribonucleoside Catabolic Process Deoxyribonucleoside Triphosphate Catabolic Process	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Enzyme-linked Receptor Protein Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Anesthetic Glial Cell Apoptotic Process Positive Regulation Of Macrophage Proliferation Monosaccharide Binding Response To Steroid Hormone Response To Ketone Fructose 1,6-bisphosphate Metabolic Process Signal Complex Assembly Regulation Of Apoptotic Signaling Pathway Response To Cobalt Ion Substrate-dependent Cell Migration, Cell Extension Ephrin Receptor Signaling Pathway Gluconeogenesis Hexose Biosynthetic Process Fibroblast Apoptotic Process Regulation Of Leukocyte Proliferation Cysteine-type Endopeptidase Activity Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Negative Regulation Of Cell Adhesion Cytosol Enzyme Activator Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Response To Metal Ion Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Steroid Hormone Stimulus Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Anatomical Structure Morphogenesis Animal Organ Formation Positive Regulation Of Cyclase Activity Positive Regulation Of Apoptotic Process Negative Regulation Of Cell-cell Adhesion Regulation Of Cell Migration Platelet Formation Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Cytoplasm Carbohydrate Biosynthetic Process Fructose-1-phosphate Aldolase Activity Prostate Induction Negative Regulation Of Apoptotic Signaling Pathway Response To Lipid
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