Wiki-Pi
About
Search
People
Updates
Search
COL2A1 and LOXL4
Number of citations of the paper that reports this interaction (PubMedID
11292829
)
0
Data Source:
HPRD
(in vitro)
COL2A1
LOXL4
Description
collagen type II alpha 1 chain
lysyl oxidase like 4
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type II Trimer
Collagen Type XI Trimer
Basement Membrane
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Region
Extracellular Space
Membrane
Receptor Complex
Extracellular Exosome
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Protein-lysine 6-oxidase Activity
Copper Ion Binding
Protein Binding
Oxidoreductase Activity
Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor
Metal Ion Binding
Biological Process
Skeletal System Development
Cartilage Condensation
Ossification
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Collagen Fibril Organization
Notochord Development
Limb Morphogenesis
Inner Ear Morphogenesis
Animal Organ Development
Skeletal System Morphogenesis
System Development
Inner Ear Development
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Bone Development
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Collagen Fibril Organization
Pathways
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Developmental Lineage of Pancreatic Ductal Cells
Elastic fibre formation
Crosslinking of collagen fibrils
Drugs
Collagenase clostridium histolyticum
Diseases
Osteoarthritis with mild chondrodysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS
Lymphocyte count (
32888494
)
Macular thickness (
30535121
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Triglyceride levels (
32902719
)
Body mass index (
29273807
)
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Height (
31562340
)
Multiple system atrophy (
27629089
)
Serum metabolite levels (
33031748
)
Interacting Genes
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
15 interacting genes:
AP1M2
APOE
CDC37
COL2A1
ECSIT
EXOC6
KDM1A
LONP1
MAST1
MTDH
PRMT6
RAD23A
RNF32
SUV39H1
TRIP13
Entrez ID
1280
84171
HPRD ID
00361
09538
Ensembl ID
ENSG00000139219
ENSG00000138131
Uniprot IDs
P02458
Q96JB6
PDB IDs
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6HG7
6NIX
7NZE
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Animal Organ Development
Cartilage Development
Extracellular Matrix Binding
Platelet Alpha Granule Lumen
Developmental Process
Cell Surface
Extracellular Matrix Organization
Extracellular Structure Organization
Animal Organ Morphogenesis
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Response To Wounding
Anatomical Structure Morphogenesis
Bone Development
Heparin Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Glial Cell Differentiation
Basement Membrane
Positive Regulation Of Cell Motility
Platelet-derived Growth Factor Binding
Golgi Lumen
Tube Morphogenesis
Positive Regulation Of Locomotion
Angiogenesis
Regulation Of Cell Adhesion
Extracellular Exosome
Proteoglycan Binding
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Skin Development
Regulation Of Anatomical Structure Morphogenesis
Cell Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Bone Mineralization
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Fibroblast Proliferation
Chondrocyte Differentiation
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Gliogenesis
Positive Regulation Of Phosphorylation
Collagen Metabolic Process
Regulation Of Extracellular Matrix Organization
Regulation Of Glial Cell Differentiation
Connective Tissue Development
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?