COL2A1 and TGFBI

Number of citations of the paper that reports this interaction (PMID 9061001)
26

Data Source:
HPRD (in vitro)

		COL2A1	TGFBI
Gene Name		collagen, type II, alpha 1	transforming growth factor, beta-induced, 68kDa
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Integrin Binding Protein Binding Collagen Binding Extracellular Matrix Binding
	Biological Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Proliferation Extracellular Matrix Organization Response To Stimulus
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Amyloids
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A	10 interactors: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FN1
Entrez ID		1280	7045
HPRD ID		00361	03409
Ensembl ID		ENSG00000139219	ENSG00000120708
Uniprot IDs		P02458	Q15582
PDB IDs		1U5M 2FSE 2SEB	1X3B 2LTB 2VXP
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis	Extracellular Matrix Disassembly Collagen Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Locomotion Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Axon Guidance Cardiovascular System Development Catabolic Process Platelet Activation Blood Vessel Development Cell Morphogenesis Axonogenesis Vasculature Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Amino Acid Stimulus Collagen Fibril Organization Cell Differentiation Neuron Projection Morphogenesis Developmental Process Vesicle-mediated Transport Neuron Projection Development Receptor-mediated Endocytosis Generation Of Neurons Cell Projection Morphogenesis Cell Part Morphogenesis System Development Protein Heterotrimerization Neurogenesis Response To Amino Acid Blood Coagulation Neuron Development Hemostasis Cell Development Response To External Stimulus Glomerular Basement Membrane Development Anatomical Structure Formation Involved In Morphogenesis Multicellular Organismal Development Sensory Perception Of Sound Anatomical Structure Development Neuron Differentiation Cell Projection Organization Cellular Response To Acid Chemical
Tagcloud ?		ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	alignment arrangements articular bigh3 biglycan cartilage chondrocytic collagen collagens crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound
Tagcloud (Difference) ?		ablated alcian alizarin bones brdu chondrocyte chondrocytes chondrodysplasia dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	alignment arrangements articular bigh3 biglycan chondrocytic collagen crossing decorin forming healing heterozygous knockout maintaining matrix metalloproteinase mineral mmp13 plates preparation safranin skeletal smaller transforming trichrome tumorigenesis wound
Tagcloud (Intersection) ?		cartilage collagens