COL2A1 and HTRA1

Number of citations of the paper that reports this interaction (PMID 15101818)
18

Data Source:
HPRD (two hybrid)

		COL2A1	HTRA1
Gene Name		collagen, type II, alpha 1	HtrA serine peptidase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Space Cytosol Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Serine-type Endopeptidase Activity Insulin-like Growth Factor Binding Serine-type Peptidase Activity
	Biological Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of Cell Growth Proteolysis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Defense Response To Virus Dentinogenesis
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23455636 23536807 20861866 21665990) Age-related macular degeneration (CNV vs. GA) ( 22705344) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Age-related macular degeneration (wet) ( 17053108)
Protein-Protein Interactions		33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A	18 interactors: APOE BMP4 CAST CDYL COL1A1 COL2A1 COL3A1 COX5A CSNK2B FAM46A FCHSD2 GDF5 GOLGA2 IMPDH1 LRP10 NOS3 PARD6B XIAP
Entrez ID		1280	5654
HPRD ID		00361	03725
Ensembl ID		ENSG00000139219	ENSG00000166033
Uniprot IDs		P02458	Q92743
PDB IDs		1U5M 2FSE 2SEB	2JOA 2YTW 3NUM 3NWU 3NZI 3TJN 3TJO 3TJQ
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Presynaptic Membrane Organization Anatomical Structure Morphogenesis Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Growth Factor Stimulus Regulation Of Cell Migration Response To Growth Factor Negative Regulation Of Cell Death Regulation Of Cell Motility Endochondral Ossification Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Presynaptic Membrane Organization Generation Of Neurons Regulation Of Locomotion Regulation Of Cellular Component Movement Neuron Differentiation Cell Morphogenesis Involved In Differentiation Limb Morphogenesis Neurogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Artery Morphogenesis Cartilage Development Regulation Of Signaling Limb Development Collagen Fibril Organization Collagen Catabolic Process Artery Development Neuron Projection Development Regulation Of Cell Development Cellular Response To Organic Substance Cardiovascular System Development Blood Vessel Development Connective Tissue Development Collagen Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Differentiation Endochondral Bone Morphogenesis Endothelial Tube Morphogenesis Vasculature Development Multicellular Organismal Macromolecule Metabolic Process Chondrocyte Differentiation Skeletal System Development Multicellular Organismal Metabolic Process Neuron Development Regulation Of Apoptotic Process Axon Development
Tagcloud ?		ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Difference) ?		ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	amd arteriopathy biosynthetic carasil elevates elucidating fibulin fostered hits infarcts interplay ix leukoencephalopathy macular metalloporphyrin modulators mpps multitude oligomerization porphyrin porphyrins ppp protoporphyria protoporphyrin seek shed subcortical unravel
Tagcloud (Intersection) ?