COL2A1 and COL6A1

Number of citations of the paper that reports this interaction (PMID 1544908)
42

Data Source:
HPRD (in vitro)

		COL2A1	COL6A1
Gene Name		collagen, type II, alpha 1	collagen, type VI, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type II Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Lysosomal Membrane Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Sarcolemma Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Binding
	Biological Process	Skeletal System Development Cartilage Condensation Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Axon Guidance Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Notochord Development Inner Ear Morphogenesis Cartilage Development Palate Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Osteoblast Differentiation Cell Adhesion Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation Protein Heterotrimerization Cellular Response To Amino Acid Stimulus
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A	9 interactors: COL2A1 DCN DNAJB11 FGF7 LAMB1 LGALS3BP MAG PDGFA PDGFB
Entrez ID		1280	1291
HPRD ID		00361	00370
Ensembl ID		ENSG00000139219	ENSG00000142156
Uniprot IDs		P02458	P12109
PDB IDs		1U5M 2FSE 2SEB
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Connective Tissue Development Cartilage Development Skeletal System Development Anatomical Structure Morphogenesis Organ Morphogenesis System Development Multicellular Organismal Development Tissue Development Platelet Degranulation Anatomical Structure Development Positive Regulation Of Cell Migration Bone Development Developmental Process Positive Regulation Of Cell Motility Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Growth Plate Cartilage Development Response To Wounding Extracellular Matrix Disassembly Organ Development Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Cellular Response To Growth Factor Stimulus Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Hemostasis Response To Growth Factor Locomotion Collagen Catabolic Process Endochondral Bone Growth Regulation Of Epithelial Cell Migration Collagen Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Involved In Endochondral Bone Morphogenesis Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Response To External Stimulus Regulation Of Cell Migration Organ Growth Platelet Activation Regulation Of Cell Motility Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Positive Regulation Of Endothelial Cell Migration Regulation Of Locomotion Bone Morphogenesis	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Organ Morphogenesis Negative Regulation Of Phospholipid Biosynthetic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Chemotaxis Locomotion Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Wounding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To Organic Substance Extracellular Matrix Disassembly Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Positive Regulation Of Cell Division Response To External Stimulus Organ Development Regulation Of Branching Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Cellular Response To Organic Substance Negative Regulation Of Platelet Activation Positive Regulation Of Epithelial Cell Proliferation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Migration Wound Healing Positive Chemotaxis Branching Involved In Salivary Gland Morphogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Autophosphorylation Regulation Of Cell Motility Regulation Of Platelet Activation Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Anatomical Structure Morphogenesis Response To Stimulus Regulation Of Locomotion
Tagcloud ?		ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	6365g aetiologies bethlem bioinformaticians commercialisation consumer definitively eventual expertise faced flagged geneticists gly2122val hitherto journey myopathy neuromuscular pointed pursued realising reassessment sanger sidetracked son table uncharacterised unprecedented
Tagcloud (Difference) ?		ablated alcian alizarin bones brdu cartilage chondrocyte chondrocytes chondrodysplasia collagens dysregulated endochondral flox histomorphometrically hyperactivation hypertrophic ihh ire1 microdissected mineralization ossification plate rays shortening stains xbp1 xbp1cartdeltaex2 xbp1flox zones	6365g aetiologies bethlem bioinformaticians commercialisation consumer definitively eventual expertise faced flagged geneticists gly2122val hitherto journey myopathy neuromuscular pointed pursued realising reassessment sanger sidetracked son table uncharacterised unprecedented
Tagcloud (Intersection) ?