COL2A1 and MAG

Number of citations of the paper that reports this interaction (PubMedID 2446864)
56

Data Source:
HPRD (in vitro)

		COL2A1	MAG
Description		collagen type II alpha 1 chain	myelin associated glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Basement Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix	Plasma Membrane Membrane Paranode Region Of Axon Myelin Sheath Adaxonal Region Myelin Sheath Compact Myelin Schmidt-Lanterman Incisure Membrane Raft Mesaxon
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Signaling Receptor Binding Lipid Binding Protein Kinase Binding Carbohydrate Binding Sialic Acid Binding Protein Homodimerization Activity Ganglioside GT1b Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Collagen Fibril Organization Notochord Development Limb Morphogenesis Inner Ear Morphogenesis Animal Organ Development Skeletal System Morphogenesis System Development Inner Ear Development Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Cell Adhesion Nervous System Development Negative Regulation Of Neuron Projection Development Transmission Of Nerve Impulse Substantia Nigra Development Central Nervous System Myelination Negative Regulation Of Axon Extension Axon Regeneration Positive Regulation Of Myelination Central Nervous System Myelin Formation Myelination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Astrocyte Differentiation Cellular Response To Mechanical Stimulus Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells	Axonal growth inhibition (RHOA activation) Basigin interactions EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Collagenase clostridium histolyticum
Diseases		Osteoarthritis with mild chondrodysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS		Lymphocyte count ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A	18 interacting genes: APP COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 COL9A1 COL9A2 COL9A3 FN1 FYN MAP1B MBP NGFR PLP1 PRNP RTN4R
Entrez ID		1280	4099
HPRD ID		00361	01160
Ensembl ID		ENSG00000139219	ENSG00000105695
Uniprot IDs		P02458	P20916 Q53ES7
PDB IDs		1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6HG7 6NIX 7NZE
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Region Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Animal Organ Development Cartilage Development Extracellular Matrix Binding Platelet Alpha Granule Lumen Developmental Process Cell Surface Extracellular Matrix Organization Extracellular Structure Organization Animal Organ Morphogenesis Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Response To Wounding Anatomical Structure Morphogenesis Bone Development Heparin Binding Positive Regulation Of Cell Migration Positive Regulation Of Glial Cell Differentiation Basement Membrane Positive Regulation Of Cell Motility Platelet-derived Growth Factor Binding Golgi Lumen Tube Morphogenesis Positive Regulation Of Locomotion Angiogenesis Regulation Of Cell Adhesion Extracellular Exosome Proteoglycan Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Bone Mineralization Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Chondrocyte Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Gliogenesis Positive Regulation Of Phosphorylation Collagen Metabolic Process Regulation Of Extracellular Matrix Organization Regulation Of Glial Cell Differentiation Connective Tissue Development	Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Platelet-derived Growth Factor Binding Endoplasmic Reticulum Lumen Extracellular Matrix Fibrillar Collagen Trimer Basement Membrane Collagen Type IX Trimer Extracellular Matrix Structural Constituent Anatomical Structure Morphogenesis Skin Development Extracellular Matrix Organization Extracellular Structure Organization Collagen Fibril Organization System Development Cellular Response To Amino Acid Stimulus Protease Binding Extracellular Region Response To Amino Acid Cellular Response To Amyloid-beta Regulation Of Dendritic Spine Maintenance Developmental Process Proteoglycan Binding Regulation Of Postsynapse Organization Perikaryon Response To Amyloid-beta Animal Organ Morphogenesis Response To Mechanical Stimulus Cartilage Development Basement Membrane Organization Type 5 Metabotropic Glutamate Receptor Binding Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Response To Xenobiotic Stimulus Collagen Type XI Trimer Negative Regulation Of Dendritic Spine Maintenance Neuron Projection Organization Regulation Of Synapse Organization Growth Cone Integrin Binding Response To Growth Factor Blood Vessel Development Central Nervous System Development Sensory Perception Of Mechanical Stimulus Nervous System Process Heparin Binding Homeostatic Process Limb Joint Morphogenesis Cellular Developmental Process
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