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COL2A1 and PRELP
Number of citations of the paper that reports this interaction (PubMedID
11847210
)
0
Data Source:
HPRD
(in vitro)
COL2A1
PRELP
Description
collagen type II alpha 1 chain
proline and arginine rich end leucine rich repeat protein
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type II Trimer
Collagen Type XI Trimer
Basement Membrane
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Extracellular Matrix
Extracellular Region
Extracellular Space
Golgi Lumen
Extracellular Matrix
Lysosomal Lumen
Extracellular Exosome
Extracellular Vesicle
Molecular Function
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent
Heparin Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Biological Process
Skeletal System Development
Cartilage Condensation
Ossification
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Collagen Fibril Organization
Notochord Development
Limb Morphogenesis
Inner Ear Morphogenesis
Animal Organ Development
Skeletal System Morphogenesis
System Development
Inner Ear Development
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Bone Development
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Skeletal System Development
Cellular Senescence
Pathways
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Developmental Lineage of Pancreatic Ductal Cells
Keratan sulfate biosynthesis
Keratan sulfate degradation
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Collagenase clostridium histolyticum
Diseases
Osteoarthritis with mild chondrodysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS
Lymphocyte count (
32888494
)
Macular thickness (
30535121
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Triglyceride levels (
32902719
)
Attention deficit hyperactivity disorder (inattention symptoms) (
32595297
)
Interacting Genes
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
6 interacting genes:
COL1A1
COL2A1
FBLN2
FN1
HSPG2
NID1
Entrez ID
1280
5549
HPRD ID
00361
03556
Ensembl ID
ENSG00000139219
ENSG00000188783
Uniprot IDs
P02458
P51888
PDB IDs
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6HG7
6NIX
7NZE
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix
Extracellular Region
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Animal Organ Development
Cartilage Development
Extracellular Matrix Binding
Platelet Alpha Granule Lumen
Developmental Process
Cell Surface
Extracellular Matrix Organization
Extracellular Structure Organization
Animal Organ Morphogenesis
Endoplasmic Reticulum Lumen
Response To Mechanical Stimulus
Response To Wounding
Anatomical Structure Morphogenesis
Bone Development
Heparin Binding
Positive Regulation Of Cell Migration
Positive Regulation Of Glial Cell Differentiation
Basement Membrane
Positive Regulation Of Cell Motility
Platelet-derived Growth Factor Binding
Golgi Lumen
Tube Morphogenesis
Positive Regulation Of Locomotion
Angiogenesis
Regulation Of Cell Adhesion
Extracellular Exosome
Proteoglycan Binding
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Skin Development
Regulation Of Anatomical Structure Morphogenesis
Cell Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Bone Mineralization
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Fibroblast Proliferation
Chondrocyte Differentiation
Positive Regulation Of MiRNA Metabolic Process
Positive Regulation Of Gliogenesis
Positive Regulation Of Phosphorylation
Collagen Metabolic Process
Regulation Of Extracellular Matrix Organization
Regulation Of Glial Cell Differentiation
Connective Tissue Development
Extracellular Matrix Structural Constituent
Extracellular Matrix
Proteoglycan Binding
Basement Membrane
Regulation Of Cell-substrate Adhesion
Regulation Of Cell Adhesion
Fibrillar Collagen Trimer
Platelet-derived Growth Factor Binding
Positive Regulation Of Cell-substrate Adhesion
Extracellular Region
Cartilage Development Involved In Endochondral Bone Morphogenesis
Endochondral Ossification
Extracellular Matrix Binding
Extracellular Matrix Organization
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Extracellular Structure Organization
Anatomical Structure Formation Involved In Morphogenesis
Endoplasmic Reticulum Lumen
Collagen Fibril Organization
Collagen Binding
Cellular Response To Vitamin E
Collagen Trimer
System Development
Cartilage Development
Collagen Type I Trimer
Protease Binding
Cellular Response To Fluoride
Positive Regulation Of Cell Adhesion
Cell-matrix Adhesion
Collagen V Binding
Skeletal System Morphogenesis
Ossification
Collagen Type II Trimer
Negative Regulation Of Monocyte Activation
Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate
CAF-1 Complex
Animal Organ Development
Calcium Ion Binding
Response To Fluoride
Sensory Perception Of Mechanical Stimulus
Sensory Perception Of Sound
Extracellular Space
Calcium-independent Cell-matrix Adhesion
Integrin Binding
Cell-substrate Adhesion
Collagen Type XI Trimer
Anterior Head Development
Intramembranous Ossification
Visual Perception
Skeletal System Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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