ACKR2 and CCL2

Number of citations of the paper that reports this interaction (PubMedID 9364936)
0

Data Source:
HPRD (in vivo)

		ACKR2	CCL2
Description		atypical chemokine receptor 2	C-C motif chemokine ligand 2
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity	Protein Kinase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway	Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Positive Regulation Of Cell Migration Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Synaptic Transmission, Glutamatergic Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Calcium Ion Import Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling NFE2L2 regulating inflammation associated genes
Drugs			Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)	Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B	28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2
Entrez ID		1238	6347
HPRD ID		09095	01149
Ensembl ID		ENSG00000144648	ENSG00000108691
Uniprot IDs		O00590	P13500
PDB IDs		8GO9 8J8V 8J8Z	1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9 7SO0 7XA3 8FJ0
Enriched GO Terms of Interacting Partners?		Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Chemokine Activity Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration G Protein-coupled Receptor Signaling Pathway Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Motility CCR Chemokine Receptor Binding Myeloid Leukocyte Migration Antimicrobial Humoral Response Leukocyte Migration Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Cytokine Activity Humoral Immune Response Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Immune System Process Defense Response Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Positive Regulation Of Cell Motility Defense Response To Other Organism Positive Regulation Of Locomotion Extracellular Space Response To External Biotic Stimulus Calcium-mediated Signaling Regulation Of Cell Migration Extracellular Region Mononuclear Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Killing Of Cells Of Another Organism Monocyte Chemotaxis Response To Other Organism Response To Stress Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Lipopolysaccharide Intracellular Calcium Ion Homeostasis Regulation Of Neuroinflammatory Response
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