ACKR2 and CCL4

Number of citations of the paper that reports this interaction (PMID 9405404)
30

Data Source:
HPRD (in vivo)

		ACKR2	CCL4
Gene Name		atypical chemokine receptor 2	chemokine (C-C motif) ligand 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	Cytokine Activity Protein Binding Chemokine Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway	Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell-cell Signaling Response To Virus Response To Toxic Substance Negative Regulation By Host Of Viral Transcription Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8	8 interactors: ACKR2 CCL3 CCR1 CCR3 CCR5 CCR8 CXCL8 SLC30A2
Entrez ID		1238	6351
HPRD ID		09095	01657
Ensembl ID		ENSG00000144648
Uniprot IDs		O00590	P13236
PDB IDs			1HUM 1HUN 1JE4 2FFK 2FIN 2X6L 3TN2
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis	Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Positive Regulation Of Cytosolic Calcium Ion Concentration Inflammatory Response Cytokine-mediated Signaling Pathway Cytosolic Calcium Ion Homeostasis Locomotion Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Leukocyte Chemotaxis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Response To External Stimulus Cellular Ion Homeostasis Cellular Response To Organic Substance Cell Chemotaxis Metal Ion Homeostasis Cellular Chemical Homeostasis G-protein Coupled Receptor Signaling Pathway Ion Homeostasis Leukocyte Migration Immune Response Defense Response Cellular Homeostasis Response To Organic Substance Positive Regulation Of Leukocyte Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Leukocyte Migration Chemical Homeostasis Calcium-mediated Signaling Cell Surface Receptor Signaling Pathway Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Positive Regulation Of Behavior Dendritic Cell Chemotaxis Regulation Of Chemotaxis Second-messenger-mediated Signaling Immune System Process Cellular Response To Lipopolysaccharide Cellular Response To Molecule Of Bacterial Origin Neutrophil Activation Regulation Of Ion Homeostasis Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Response To Cholesterol Regulation Of Behavior Dendritic Cell Migration
Tagcloud ?			acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Difference) ?			acetyltransferase boxes cat chloramphenicol coinciding construct constructs fibrogenesis fibrogenic fibrotic hepatic igfiir inducer latent livers m6p mannose mutagenized p75 participating participation quiescent reporter repressor residing stellate stimulant tetrachloride transcript
Tagcloud (Intersection) ?