CCL2 and VCAN

Number of citations of the paper that reports this interaction (PMID 11083865)
32

Data Source:
HPRD (in vitro)

		CCL2	VCAN
Gene Name		chemokine (C-C motif) ligand 2	versican
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Endocytic Vesicle Dendrite Perikaryon Axon Terminus C-fiber Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Lumen Membrane Extracellular Matrix Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Kinase Activity Receptor Binding Chemokine Activity Heparin Binding CCR2 Chemokine Receptor Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Endothelial Cell Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Positive Regulation Of Cellular Extravasation Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Humoral Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger JAK-STAT Cascade Aging Regulation Of Cell Shape Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Bacterium Organ Morphogenesis Response To Gamma Radiation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Response To Activity Negative Regulation Of Angiogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Cellular Homeostasis Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Lipopolysaccharide-mediated Signaling Pathway Response To Progesterone Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin B3 Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Cellular Response To Drug Cellular Response To Macrophage Colony-stimulating Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Response To Amino Acid Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Maternal Process Involved In Female Pregnancy Maternal Process Involved In Parturition Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To ATP Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Calcium Ion Import Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Skeletal System Development Osteoblast Differentiation Carbohydrate Metabolic Process Cell Adhesion Multicellular Organismal Development Central Nervous System Development Heart Development Cell Recognition Glial Cell Migration Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) ATF4 activates genes GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide ligand-binding receptors Chemokine receptors bind chemokines PERK regulates gene expression Unfolded Protein Response (UPR)	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Mimosine Danazol
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233)	Major depressive disorder ( 20516156)
Protein-Protein Interactions		11 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 MMP1 MMP3 MMP8 VCAN	24 interactors: ACAN ADAMTS1 CCL2 CCL20 CCL21 CCL5 CCL8 CD44 CXCL10 CXCL12 CXCR3 FBLN1 FBLN2 FBN1 HAPLN1 ITGA4 ITGB1 PF4 PLA2G2A SELL SELP SELPLG TNR XCL1
Entrez ID		6347	1462
HPRD ID		01149	00340
Ensembl ID		ENSG00000108691	ENSG00000038427
Uniprot IDs		P13500	P13611 Q59FG9 Q6MZK8 Q86W61
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Locomotion Inflammatory Response Chemotaxis G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Defense Response Extracellular Matrix Organization Extracellular Structure Organization Dendritic Cell Chemotaxis Response To Stress Cellular Metal Ion Homeostasis Positive Regulation Of Protein Oligomerization Cellular Cation Homeostasis Cellular Ion Homeostasis Neutrophil Activation Metal Ion Homeostasis Dendritic Cell Migration Response To External Stimulus Cellular Chemical Homeostasis Regulation Of Protein Oligomerization Ion Homeostasis Leukocyte Migration Cell Surface Receptor Signaling Pathway Immune Response Immune System Process Cellular Homeostasis Cellular Defense Response Cell Migration Chemical Homeostasis Receptor-mediated Endocytosis Cell Motility Leukocyte Chemotaxis Viral Process Response To Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Leukocyte Migration Cell Migration Cell Motility Regulation Of Leukocyte Migration Locomotion Positive Regulation Of Leukocyte Migration Cell Chemotaxis Movement Of Cell Or Subcellular Component Regulation Of Lymphocyte Migration Positive Regulation Of Locomotion Positive Regulation Of T Cell Migration Regulation Of T Cell Migration Positive Regulation Of Chemotaxis Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Behavior Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Motility Cell Adhesion Positive Regulation Of Cellular Component Movement Regulation Of Chemotaxis Regulation Of Cell Migration Inflammatory Response Regulation Of Cell Motility Immune System Process Regulation Of Behavior Leukocyte Chemotaxis Regulation Of Locomotion Regulation Of Cellular Component Movement Chemokine-mediated Signaling Pathway Response To Other Organism Extracellular Matrix Organization Extracellular Structure Organization Response To Biotic Stimulus Regulation Of Immune System Process Cellular Extravasation Lymphocyte Migration Response To External Stimulus Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Leukocyte Cell-cell Adhesion Leukocyte Tethering Or Rolling Single Organismal Cell-cell Adhesion Response To Organic Substance Defense Response Positive Regulation Of Cell Adhesion Lymphocyte Chemotaxis T Cell Migration Cellular Response To Cytokine Stimulus
Tagcloud ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Difference) ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes wnt
Tagcloud (Intersection) ?