CCL2 and CCR1

Number of citations of the paper that reports this interaction (PMID 8631787)
20

Data Source:
HPRD (in vitro)

		CCL2	CCR1
Gene Name		chemokine (C-C motif) ligand 2	chemokine (C-C motif) receptor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Endocytic Vesicle Dendrite Perikaryon Axon Terminus C-fiber Synapse Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Protein Kinase Activity Receptor Binding Chemokine Activity Heparin Binding CCR2 Chemokine Receptor Binding	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Endothelial Cell Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Positive Regulation Of Cellular Extravasation Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Humoral Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger JAK-STAT Cascade Aging Regulation Of Cell Shape Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Bacterium Organ Morphogenesis Response To Gamma Radiation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Response To Activity Negative Regulation Of Angiogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Cellular Homeostasis Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Lipopolysaccharide-mediated Signaling Pathway Response To Progesterone Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin B3 Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Cellular Response To Drug Cellular Response To Macrophage Colony-stimulating Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Response To Amino Acid Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Maternal Process Involved In Female Pregnancy Maternal Process Involved In Parturition Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To ATP Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Calcium Ion Import Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Metabolic Process Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) ATF4 activates genes GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide ligand-binding receptors Chemokine receptors bind chemokines PERK regulates gene expression Unfolded Protein Response (UPR)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Mimosine Danazol
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233)	Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140)
Protein-Protein Interactions		11 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 MMP1 MMP3 MMP8 VCAN	20 interactors: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		6347	1230
HPRD ID		01149	03101
Ensembl ID		ENSG00000108691	ENSG00000163823
Uniprot IDs		P13500	P32246 Q5U003
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4	1Y5D
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Locomotion Inflammatory Response Chemotaxis G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Defense Response Extracellular Matrix Organization Extracellular Structure Organization Dendritic Cell Chemotaxis Response To Stress Cellular Metal Ion Homeostasis Positive Regulation Of Protein Oligomerization Cellular Cation Homeostasis Cellular Ion Homeostasis Neutrophil Activation Metal Ion Homeostasis Dendritic Cell Migration Response To External Stimulus Cellular Chemical Homeostasis Regulation Of Protein Oligomerization Ion Homeostasis Leukocyte Migration Cell Surface Receptor Signaling Pathway Immune Response Immune System Process Cellular Homeostasis Cellular Defense Response Cell Migration Chemical Homeostasis Receptor-mediated Endocytosis Cell Motility Leukocyte Chemotaxis Viral Process Response To Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Cell Chemotaxis Chemotaxis Inflammatory Response Locomotion Cell Migration Cell Motility Immune Response Defense Response Response To External Stimulus Movement Of Cell Or Subcellular Component Monocyte Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Cellular Calcium Ion Homeostasis Immune System Process Calcium Ion Homeostasis Positive Regulation Of Leukocyte Migration Response To Stress Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Chemical Homeostasis Cellular Metal Ion Homeostasis Positive Regulation Of Behavior Regulation Of Chemotaxis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Chemotaxis Regulation Of Behavior Positive Regulation Of Cellular Component Movement Ion Homeostasis Positive Regulation Of Locomotion Cellular Response To Stimulus Positive Regulation Of Calcium Ion Transport Regulation Of Cell Migration Cell-cell Signaling Regulation Of Cell Motility Leukocyte Chemotaxis Response To Stimulus Lipopolysaccharide-mediated Signaling Pathway Eosinophil Chemotaxis Regulation Of Locomotion Homeostatic Process Regulation Of Cellular Component Movement Eosinophil Migration Cellular Homeostasis
Tagcloud ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	7b11 aminoxypentane augmented broadening ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated mip monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?