CCL2 and MMP8

Number of citations of the paper that reports this interaction (PMID 12149192)
92

Data Source:
HPRD (in vivo, in vitro)

		CCL2	MMP8
Gene Name		chemokine (C-C motif) ligand 2	matrix metallopeptidase 8 (neutrophil collagenase)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Rough Endoplasmic Reticulum Endocytic Vesicle Dendrite Perikaryon Axon Terminus C-fiber Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Protein Kinase Activity Receptor Binding Chemokine Activity Heparin Binding CCR2 Chemokine Receptor Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	MAPK Cascade Angiogenesis Response To Hypoxia Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Endothelial Cell Proliferation Leukocyte Migration Involved In Inflammatory Response Monocyte Chemotaxis Positive Regulation Of Cellular Extravasation Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Humoral Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger JAK-STAT Cascade Aging Regulation Of Cell Shape Response To Heat Response To Wounding Response To Mechanical Stimulus Response To Bacterium Organ Morphogenesis Response To Gamma Radiation Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Response To Activity Negative Regulation Of Angiogenesis Viral Genome Replication Cytokine-mediated Signaling Pathway Cellular Homeostasis Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Organ Regeneration Lipopolysaccharide-mediated Signaling Pathway Response To Progesterone Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Positive Regulation Of Collagen Biosynthetic Process Response To Vitamin B3 Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Cellular Response To Drug Cellular Response To Macrophage Colony-stimulating Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Response To Amino Acid Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Ethanol Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Synaptic Transmission Positive Regulation Of T Cell Activation Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Maternal Process Involved In Female Pregnancy Maternal Process Involved In Parturition Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To ATP Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To High Density Lipoprotein Particle Stimulus Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Positive Regulation Of Calcium Ion Import Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) ATF4 activates genes GPCR ligand binding Metabolic disorders of biological oxidation enzymes Peptide ligand-binding receptors Chemokine receptors bind chemokines PERK regulates gene expression Unfolded Protein Response (UPR)	Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs		Mimosine Danazol	Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione Glycinamid Batimastat N-{2-[(4\'-CYANO-1,1\'-BIPHENYL-4-YL)OXY]ETHYL}-N\'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID (1R)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Crohn's disease ( 22412388 21102463) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233)	Prostate cancer ( 23535732)
Protein-Protein Interactions		11 interactors: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 MMP1 MMP3 MMP8 VCAN	7 interactors: ACAN BCAN CCL2 TFPI TIMP2 UBC UMOD
Entrez ID		6347	4317
HPRD ID		01149	00385
Ensembl ID		ENSG00000108691	ENSG00000118113
Uniprot IDs		P13500	P22894
PDB IDs		1DOK 1DOL 1DOM 1DON 1MCA 1ML0 2BDN 2NZ1 3IFD 4DN4	1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Locomotion Inflammatory Response Chemotaxis G-protein Coupled Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Response To Organic Substance Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Defense Response Extracellular Matrix Organization Extracellular Structure Organization Dendritic Cell Chemotaxis Response To Stress Cellular Metal Ion Homeostasis Positive Regulation Of Protein Oligomerization Cellular Cation Homeostasis Cellular Ion Homeostasis Neutrophil Activation Metal Ion Homeostasis Dendritic Cell Migration Response To External Stimulus Cellular Chemical Homeostasis Regulation Of Protein Oligomerization Ion Homeostasis Leukocyte Migration Cell Surface Receptor Signaling Pathway Immune Response Immune System Process Cellular Homeostasis Cellular Defense Response Cell Migration Chemical Homeostasis Receptor-mediated Endocytosis Cell Motility Leukocyte Chemotaxis Viral Process Response To Stimulus Negative Regulation Of Hydrogen Peroxide Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger	Extracellular Matrix Disassembly Pathogenesis Neutrophil Migration Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Response To Vitamin B3 Helper T Cell Extravasation Negative Regulation Of Natural Killer Cell Chemotaxis Cellular Response To High Density Lipoprotein Particle Stimulus Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Metanephric Thick Ascending Limb Development Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Response To High Density Lipoprotein Particle Negative Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Metanephric Ascending Thin Limb Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Viral Life Cycle Regulation Of Cellular Protein Metabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Blood Coagulation, Extrinsic Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Mitotic Cell Cycle Leukocyte Migration MAPK Cascade Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Central Nervous System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Astrocyte Cell Migration Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of Apoptotic Cell Clearance
Tagcloud ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Difference) ?		balancing commensals deactivation directions gammadelta hedgehog hsc immunological immunology initiators kc killer kupffer mfb mutual myofibroblasts nkt pdl pericyte responds sinusoidal stellate tlr9 transdifferentiate transduces versa versatile vice vit	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Intersection) ?