ACKR2 and CCL25

Number of citations of the paper that reports this interaction (PMID 10706668)
23

Data Source:
HPRD (in vivo)

		ACKR2	CCL25
Gene Name		atypical chemokine receptor 2	chemokine (C-C motif) ligand 25
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	Hormone Activity Chemokine Activity CCR10 Chemokine Receptor Binding Chemokine Receptor Binding
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Leukocyte Migration Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8	4 interactors: ACKR2 ACKR4 CCR10 CCR9
Entrez ID		1238	6370
HPRD ID		09095	03976
Ensembl ID		ENSG00000144648	ENSG00000131142
Uniprot IDs		O00590	O15444
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis	Chemokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Chemotaxis Response To Cytokine Neutrophil Activation G-protein Coupled Receptor Signaling Pathway Locomotion Immune Response Receptor-mediated Endocytosis Response To External Stimulus Cellular Response To Organic Substance Immune System Process Endocytosis Response To Organic Substance Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Surface Receptor Signaling Pathway Cytosolic Calcium Ion Homeostasis Defense Response Vesicle-mediated Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Inflammatory Response Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Signal Transduction Leukocyte Activation Cellular Chemical Homeostasis Signaling Ion Homeostasis Cell Communication Cell Activation Cellular Homeostasis Cellular Response To Stimulus Chemical Homeostasis Cellular Defense Response Response To Stress Response To Stimulus Homeostatic Process Transport
Tagcloud ?			17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Difference) ?			17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Intersection) ?