CCL2 and CXCL17

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL2	CXCL17
Description		C-C motif chemokine ligand 2	C-X-C motif chemokine ligand 17
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding Chemoattractant Activity CCR Chemokine Receptor Binding	Protein Binding
	Biological Process	Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Positive Regulation Of Cell Migration Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Synaptic Transmission, Glutamatergic Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Calcium Ion Import Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Angiogenesis Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Differentiation Macrophage Chemotaxis Negative Regulation Of Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling NFE2L2 regulating inflammation associated genes
Drugs		Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	16 interacting genes: CCL13 CCL2 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CCL8 CXCL10 CXCL12 CXCL14 CXCL9 PF4 XCL1 XCL2
Entrez ID		6347	284340
HPRD ID		01149	18264
Ensembl ID		ENSG00000108691	ENSG00000189377
Uniprot IDs		P13500	Q6UXB2
PDB IDs		1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9 7SO0 7XA3 8FJ0
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Chemokine Activity Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration G Protein-coupled Receptor Signaling Pathway Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Motility CCR Chemokine Receptor Binding Myeloid Leukocyte Migration Antimicrobial Humoral Response Leukocyte Migration Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Cytokine Activity Humoral Immune Response Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Immune System Process Defense Response Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Positive Regulation Of Cell Motility Defense Response To Other Organism Positive Regulation Of Locomotion Extracellular Space Response To External Biotic Stimulus Calcium-mediated Signaling Regulation Of Cell Migration Extracellular Region Mononuclear Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Killing Of Cells Of Another Organism Monocyte Chemotaxis Response To Other Organism Response To Stress Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Lipopolysaccharide Intracellular Calcium Ion Homeostasis Regulation Of Neuroinflammatory Response	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Locomotion Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Leukocyte Chemotaxis Granulocyte Migration Leukocyte Migration Killing Of Cells Of Another Organism Myeloid Leukocyte Migration Defense Response To Symbiont CCR Chemokine Receptor Binding Defense Response To Other Organism Cell Migration Cell Killing Cell Motility Response To Other Organism Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Response To External Biotic Stimulus Defense Response Extracellular Space Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Binding Mononuclear Cell Migration Immune System Process Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Lymphocyte Migration Positive Regulation Of Leukocyte Migration Positive Regulation Of T Cell Migration CXCR Chemokine Receptor Binding Negative Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Lymphocyte Migration Response To Stress Positive Regulation Of Mononuclear Cell Migration
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