CCL2 and CCL15

Number of citations of the paper that reports this interaction (PubMedID 28381538)
0

Data Source:
BioGRID (pull down)

		CCL2	CCL15
Description		C-C motif chemokine ligand 2	C-C motif chemokine ligand 15
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding Chemoattractant Activity CCR Chemokine Receptor Binding	Signaling Receptor Binding Cytokine Activity Chemokine Activity Heparin Binding Chemoattractant Activity CCR Chemokine Receptor Binding
	Biological Process	Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Positive Regulation Of Cell Migration Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Synaptic Transmission, Glutamatergic Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Calcium Ion Import Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Migration Positive Regulation Of Inflammatory Response Positive Chemotaxis Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling NFE2L2 regulating inflammation associated genes
Drugs		Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233 28067908)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Upper eyelid sagging severity ( 24869959)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	3 interacting genes: CCL2 CCR1 CCR3
Entrez ID		6347	6359
HPRD ID		01149	03232
Ensembl ID		ENSG00000108691	ENSG00000275718
Uniprot IDs		P13500	Q16663
PDB IDs		1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9 7SO0 7XA3 8FJ0	2HCC 7VL9 7VLA
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Chemokine Activity Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration G Protein-coupled Receptor Signaling Pathway Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Motility CCR Chemokine Receptor Binding Myeloid Leukocyte Migration Antimicrobial Humoral Response Leukocyte Migration Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Cytokine Activity Humoral Immune Response Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Immune System Process Defense Response Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Positive Regulation Of Cell Motility Defense Response To Other Organism Positive Regulation Of Locomotion Extracellular Space Response To External Biotic Stimulus Calcium-mediated Signaling Regulation Of Cell Migration Extracellular Region Mononuclear Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Killing Of Cells Of Another Organism Monocyte Chemotaxis Response To Other Organism Response To Stress Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Lipopolysaccharide Intracellular Calcium Ion Homeostasis Regulation Of Neuroinflammatory Response	Chemokine-mediated Signaling Pathway Chemokine Receptor Activity Cell Chemotaxis Monocyte Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Cytokine Stimulus Inflammatory Response Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Calcium Ion Transport Mononuclear Cell Migration Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Leukocyte Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Regulation Of Endothelial Cell Proliferation Negative Regulation Of Natural Killer Cell Chemotaxis Cell Adhesion Cell Migration Calcium-mediated Signaling Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Chemotaxis Cell Motility CCR2 Chemokine Receptor Binding Regulation Of Leukocyte Migration Regulation Of Calcium Ion Transport Leukocyte Migration T Cell Extravasation Immune Response Astrocyte Cell Migration Defense Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Metal Ion Transport External Side Of Plasma Membrane Positive Regulation Of Glutamate Receptor Signaling Pathway
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