CCL2 and TMX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CCL2	TMX2
Description		C-C motif chemokine ligand 2	thioredoxin related transmembrane protein 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	Protein Kinase Activity Signaling Receptor Binding Cytokine Activity Protein Binding Chemokine Activity CCR2 Chemokine Receptor Binding Chemoattractant Activity CCR Chemokine Receptor Binding	Protein Binding Disulfide Oxidoreductase Activity Identical Protein Binding
	Biological Process	Angiogenesis Monocyte Chemotaxis Protein Phosphorylation Chemotaxis Inflammatory Response Immune Response Humoral Immune Response Cytoskeleton Organization Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Shape Response To Bacterium Animal Organ Morphogenesis Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Viral Genome Replication Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Cellular Homeostasis Positive Regulation Of Cell Migration Negative Regulation Of Glial Cell Apoptotic Process Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Astrocyte Cell Migration Cellular Response To Fibroblast Growth Factor Stimulus Eosinophil Chemotaxis Macrophage Chemotaxis Positive Regulation Of T Cell Activation Positive Chemotaxis Positive Regulation Of Synaptic Transmission, Glutamatergic Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Calcium Ion Import Positive Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Endothelial Cell Proliferation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Apoptotic Cell Clearance Negative Regulation Of Natural Killer Cell Chemotaxis	Brain Development
Pathways		Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling NFE2L2 regulating inflammation associated genes
Drugs		Mimosine Danazol Chondroitin sulfate
Diseases
GWAS		Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 23128233 28067908)	Autism spectrum disorder or schizophrenia ( 28540026) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neuroticism ( 29255261) Problematic alcohol use ( 32451486) Reticulocyte count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		28 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL15 CCL26 CCL4L1 CCL5 CCL8 CCR1 CCR10 CCR3 CCR5 CXCL17 CXCL8 CXCL9 MMP1 MMP3 MMP8 PF4 RNF4 SLC16A2 SLC22A1 SLC22A2 TMX2 VCAN XCL2	163 interacting genes: AGPAT3 AGPAT4 AGPAT5 AIG1 AQP6 ARV1 ASGR1 ASPH ATXN1 BDKRB1 BET1 BNIP1 BNIP2 BNIP3 BRICD5 BTN2A2 C2CD2L CCDC167 CCL2 CD81 CDIPT CDS2 CMTM7 COL8A2 COMMD8 COX20 CTSA CTXN3 CXCL16 CXorf66 CYBC1 CYP4F2 DERL1 DGAT2L6 EMD EMP3 F2RL1 FA2H FAM177A1 FAM241B FAM3C FAXDC2 FDFT1 FUNDC2 FXYD6-FXYD2 GIMAP1 GIMAP5 GJB2 HACD2 HHATL HMOX1 HMOX2 HSD17B11 HSD17B13 HTATIP2 IER3 IER3IP1 IGFBP5 INSIG2 ITGAM LEPROT LEPROTL1 LHFPL5 LRAT MALL MFF MGLL MGST3 MIP MLN MS4A1 MTNR1A NAT8 NDUFA3 NINJ2 NRM NSDHL NSG1 ORMDL2 OTULINL PAEP PEDS1-UBE2V1 PEX16 PKMYT1 PLP2 PNLIPRP1 PRAF2 PRB1 PTAFR PTPN9 RABAC1 REEP2 REEP4 RFT1 RNF24 RTP2 RUSF1 SACM1L SCAMP5 SCD SELENOK SERF1A SERF1B SERP2 SFT2D1 SFXN1 SFXN3 SLC22A2 SLC29A2 SLC35A1 SLC67A1 SLC71A2 SMAGP SMCO4 SMIM1 STATH STX12 STX3 STX7 THBD THSD7B TMBIM6 TMEM115 TMEM120A TMEM120B TMEM121 TMEM128 TMEM140 TMEM14B TMEM14C TMEM176A TMEM201 TMEM203 TMEM208 TMEM222 TMEM239 TMEM254 TMEM31 TMEM50B TMEM51 TMEM65 TMEM71 TMEM86B TMEM97 TPRG1 TRAM1L1 TREX1 TSNARE1 TSPAN2 TVP23B UBE2J1 UNC93A VAMP1 VAMP3 VAMP4 VAMP5 VAPA VAPB WFDC2 YIF1A YIPF1 YIPF2 YIPF6
Entrez ID		6347	51075
HPRD ID		01149	07159
Ensembl ID		ENSG00000108691	ENSG00000213593
Uniprot IDs		P13500	Q9Y320
PDB IDs		1DOK 1DOL 1DOM 1DON 1ML0 2BDN 2NZ1 3IFD 4DN4 4R8I 4ZK9 7SO0 7XA3 8FJ0	2DJ0
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Cell Chemotaxis Chemotaxis Locomotion Chemokine Activity Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Cell Migration G Protein-coupled Receptor Signaling Pathway Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cell Motility CCR Chemokine Receptor Binding Myeloid Leukocyte Migration Antimicrobial Humoral Response Leukocyte Migration Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Cytokine Activity Humoral Immune Response Eosinophil Chemotaxis Eosinophil Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Immune System Process Defense Response Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Defense Response To Symbiont Positive Regulation Of Cell Motility Defense Response To Other Organism Positive Regulation Of Locomotion Extracellular Space Response To External Biotic Stimulus Calcium-mediated Signaling Regulation Of Cell Migration Extracellular Region Mononuclear Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Killing Of Cells Of Another Organism Monocyte Chemotaxis Response To Other Organism Response To Stress Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Lipopolysaccharide Intracellular Calcium Ion Homeostasis Regulation Of Neuroinflammatory Response	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex SNAP Receptor Activity Cortical Endoplasmic Reticulum Protein Binding CDP-diacylglycerol Metabolic Process Vesicle-mediated Transport Lipid Biosynthetic Process Membrane Organization Nuclear Envelope Endomembrane System Membrane Docking CDP-diacylglycerol Biosynthetic Process Organelle Fusion Organelle Membrane Fusion Intracellular Transport Lipid Metabolic Process Organelle Localization By Membrane Tethering Golgi Membrane Membrane Fusion Endoplasmic Reticulum Organization Cellular Localization Establishment Of Localization In Cell Sterol Biosynthetic Process Vesicle Fusion Golgi Trans Cisterna Golgi Medial Cisterna Golgi Vesicle Transport Heme Oxidation Heme Oxygenase (decyclizing) Activity Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Nuclear Inner Membrane Response To Oxygen-glucose Deprivation Regulation Of Cellular Localization Amyloid Fibril Formation Mitochondrial Outer Membrane Steroid Biosynthetic Process Monoatomic Ion Transmembrane Transporter Activity SNARE Complex Assembly Glycerolipid Metabolic Process FFAT Motif Binding Steroid Dehydrogenase Activity Serine Import Into Mitochondrion Vesicle Docking Golgi Apparatus Heme Metabolic Process Spindle Pole Centrosome Cholesterol Biosynthetic Process
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