ACKR2 and CCL28

Number of citations of the paper that reports this interaction (PMID 10781587)
35

Data Source:
HPRD (in vivo)

		ACKR2	CCL28
Gene Name		atypical chemokine receptor 2	chemokine (C-C motif) ligand 28
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	Chemokine Activity
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway	Positive Regulation Of Cell-matrix Adhesion Chemotaxis Immune Response Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Cell Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8	6 interactors: ACKR2 CCR10 CCR3 DDI1 PSMA3 STUB1
Entrez ID		1238	56477
HPRD ID		09095	05577
Ensembl ID		ENSG00000144648
Uniprot IDs		O00590	A0N0Q3 Q9NRJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis	Chemokine-mediated Signaling Pathway Neutrophil Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Cytokine Stimulus Chemotaxis Response To Stress Positive Regulation Of Protein Ubiquitination Response To Cytokine Positive Regulation Of Chaperone-mediated Protein Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Polyubiquitination Cytosolic Calcium Ion Homeostasis Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Response To Organic Substance Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Calcium Ion Homeostasis Locomotion Signal Transduction Regulation Of Glucocorticoid Metabolic Process Defense Response Receptor-mediated Endocytosis Misfolded Or Incompletely Synthesized Protein Catabolic Process Cellular Response To Misfolded Protein Cell Surface Receptor Signaling Pathway Signaling Regulation Of Protein Catabolic Process Cell Communication Response To Misfolded Protein Cellular Metal Ion Homeostasis Proteolysis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Leukocyte Activation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Chemical Homeostasis
Tagcloud ?			17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Difference) ?			17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck tnfsf14 xcl1
Tagcloud (Intersection) ?