ACKR2 and CCL8

Number of citations of the paper that reports this interaction (PubMedID 9405404)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		ACKR2	CCL8
Description		atypical chemokine receptor 2	C-C motif chemokine ligand 8
Image
GO Annotations	Cellular Component	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity	Protein Kinase Activity Cytokine Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway	Positive Regulation Of Leukocyte Migration Calcium Ion Transport Intracellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Response To Virus Positive Regulation Of Cell Migration Killing Of Cells Of Another Organism Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Myoblast Differentiation Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Myoblast Fusion
Pathways		Chemokine receptors bind chemokines
Drugs			Pidolic acid
Diseases
GWAS		Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)	Blood protein levels ( 30072576) Crohn's disease ( 22412388) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B	20 interacting genes: ACKR1 ACKR2 ACKR4 CCL11 CCL13 CCL2 CCL26 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL17 CXCL2 CXCL6 CXCL8 MMP3 PPBP VCAN XCL2
Entrez ID		1238	6355
HPRD ID		09095	03791
Ensembl ID		ENSG00000144648	ENSG00000108700
Uniprot IDs		O00590	P80075
PDB IDs		8GO9 8J8V 8J8Z	1ESR 7S59 7S5A
Enriched GO Terms of Interacting Partners?		Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Cell Migration Inflammatory Response Leukocyte Chemotaxis Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cytokine-mediated Signaling Pathway Leukocyte Migration Antimicrobial Humoral Response Immune Response Myeloid Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Cytokine Activity Defense Response Humoral Immune Response Immune System Process Granulocyte Chemotaxis Granulocyte Migration C-C Chemokine Binding Defense Response To Symbiont Defense Response To Other Organism Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity Extracellular Space Killing Of Cells Of Another Organism CCR Chemokine Receptor Binding Response To External Biotic Stimulus Response To Stress Response To Other Organism Cellular Response To Lipopolysaccharide CXCR Chemokine Receptor Binding Cell Killing Cellular Response To Molecule Of Bacterial Origin Response To Molecule Of Bacterial Origin Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Extracellular Region Eosinophil Chemotaxis Eosinophil Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Chemotaxis Calcium-mediated Signaling Response To Lipopolysaccharide Regulation Of Cell Migration
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