ACKR2 and CCL27

Number of citations of the paper that reports this interaction (PubMedID 11821900)
0

Data Source:
HPRD (in vivo)

		ACKR2	CCL27
Description		atypical chemokine receptor 2	C-C motif chemokine ligand 27
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GO Annotations	Cellular Component	Nucleoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane External Side Of Plasma Membrane Membrane Nuclear Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Receptor Decoy Activity	Cytokine Activity Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Chemokine Receptor Binding CXCR Chemokine Receptor Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Intracellular Signal Transduction Cell Chemotaxis Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Neutrophil Chemotaxis Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Thymus and reactivation regulated chemokine levels ( 33227023) White blood cell count ( 27863252 32888494)
Interacting Genes		25 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 SNCA TMEM167B	5 interacting genes: ACKR2 CCL11 CCL5 CCR10 PF4V1
Entrez ID		1238	10850
HPRD ID		09095	05321
Ensembl ID		ENSG00000144648	ENSG00000213927
Uniprot IDs		O00590	Q5VZ77 Q9Y4X3
PDB IDs		8GO9 8J8V 8J8Z	2KUM
Enriched GO Terms of Interacting Partners?		Chemokine Activity CCR Chemokine Receptor Binding Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Chemotaxis Chemotaxis Eosinophil Migration Locomotion Antimicrobial Humoral Response Humoral Immune Response Granulocyte Chemotaxis Chemokine-mediated Signaling Pathway Granulocyte Migration Cell Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Leukocyte Chemotaxis Regulation Of Leukocyte Migration Leukocyte Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Response To External Biotic Stimulus Positive Regulation Of Locomotion Positive Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Cell Migration Chemokine Receptor Binding Response To Other Organism Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cell Migration Regulation Of Cell Motility Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Chemotaxis Cell Motility Positive Regulation Of Mononuclear Cell Migration CCR1 Chemokine Receptor Binding Regulation Of Lymphocyte Migration Immune Response Extracellular Space Positive Regulation Of Lymphocyte Migration Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration Immune System Process Regulation Of Lymphocyte Chemotaxis G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Chemotaxis	Cell Chemotaxis Chemokine-mediated Signaling Pathway Chemotaxis Locomotion Chemokine Activity Granulocyte Chemotaxis Granulocyte Migration Cell Migration Eosinophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Eosinophil Migration Cytokine-mediated Signaling Pathway Myeloid Leukocyte Migration Cell Motility Leukocyte Chemotaxis CCR Chemokine Receptor Binding Immune Response Antimicrobial Humoral Response Inflammatory Response Cytokine Activity Leukocyte Migration Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Immune System Process Chemokine Receptor Binding Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Dendritic Cell Chemotaxis Defense Response Positive Regulation Of Lymphocyte Chemotaxis Positive Regulation Of Cell Adhesion Mediated By Integrin Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Dendritic Cell Migration Regulation Of Lymphocyte Chemotaxis Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of T Cell Migration Intracellular Signaling Cassette Positive Regulation Of Lymphocyte Migration Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Actin Filament Polymerization Regulation Of T Cell Migration Regulation Of Granulocyte Chemotaxis ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Apoptotic Process Signal Transduction Response To Other Organism
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