ACKR2 and CCL3L3

Number of citations of the paper that reports this interaction (PMID 10364178)
27

Data Source:
HPRD (in vitro)

		ACKR2	CCL3L3
Gene Name		atypical chemokine receptor 2	chemokine (C-C motif) ligand 3-like 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Early Endosome Actin Filament Plasma Membrane Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding	Chemokine Activity
	Biological Process	Receptor-mediated Endocytosis Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Neutrophil Activation Chemokine-mediated Signaling Pathway	Inflammatory Response Immune Response Negative Regulation Of Cell Proliferation Cell Chemotaxis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8	2 interactors: ACKR2 CCR5
Entrez ID		1238	414062
HPRD ID		09095	14426
Ensembl ID		ENSG00000144648	ENSG00000256515
Uniprot IDs		O00590	P16619
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Chemotaxis Cell Migration Locomotion Immune Response Cell Motility Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Movement Of Cell Or Subcellular Component Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Leukocyte Migration Cellular Chemical Homeostasis Immune System Process Ion Homeostasis Cellular Homeostasis Leukocyte Chemotaxis Eosinophil Chemotaxis Leukocyte Migration Chemical Homeostasis Eosinophil Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Lymphocyte Migration Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Cell Migration Positive Regulation Of Behavior Regulation Of Cell Motility Granulocyte Chemotaxis Regulation Of Chemotaxis Homeostatic Process Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Behavior Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Monocyte Chemotaxis Negative Regulation Of Leukocyte Tethering Or Rolling Negative Regulation Of Leukocyte Migration Cellular Response To Stimulus Response To Stress Regulation Of Granulocyte Chemotaxis	Chemokine-mediated Signaling Pathway Inflammatory Response Cytokine-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Cytokine Stimulus Chemotaxis Sarcoplasmic Reticulum Calcium Ion Transport Response To Cytokine Dendritic Cell Chemotaxis Neutrophil Activation Response To Cholesterol Dendritic Cell Migration G-protein Coupled Receptor Signaling Pathway Locomotion Release Of Sequestered Calcium Ion Into Cytosol Immune Response Defense Response Regulation Of Sequestering Of Calcium Ion Entry Into Host Cell Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Cellular Defense Response Response To External Stimulus Cellular Response To Organic Substance Calcium-mediated Signaling Immune System Process Interaction With Host Leukocyte Chemotaxis Response To Organic Substance Second-messenger-mediated Signaling Cellular Response To Lipopolysaccharide Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Molecule Of Bacterial Origin Regulation Of Ion Homeostasis Cell Chemotaxis Cytosolic Calcium Ion Homeostasis Cell Surface Receptor Signaling Pathway Leukocyte Migration MAPK Cascade Response To Stress
Tagcloud ?			cartilage ccl20 ccl4l1 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle
Tagcloud (Difference) ?			cartilage ccl20 ccl4l1 ccl4l2 ccl8 cxcl2 cxcl3 damps hmga hmgb hmgb1 hmgb2 hmgi hmgn hmgs immunohistological lef1 nfkappab1 nfkappab2 oa perpetuate s100a s100a11 spondins sry subchondral untangle
Tagcloud (Intersection) ?