ASF1A and ZDHHC17

Number of citations of the paper that reports this interaction (PubMedID 24705354)
111

Data Source:
BioGRID (two hybrid)

		ASF1A	ZDHHC17
Description		anti-silencing function 1A histone chaperone	zDHHC palmitoyltransferase 17
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Protein-containing Complex Site Of Double-strand Break	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse Glutamatergic Synapse Perforant Pathway To Dendrate Granule Cell Synapse Postsynaptic Golgi Apparatus
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Histone Chaperone Activity	Signaling Receptor Binding Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Osteoblast Differentiation DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response Replication Fork Processing Muscle Cell Differentiation Protein Localization To Chromatin DNA Repair-dependent Chromatin Remodeling	Axonogenesis Protein Palmitoylation Lipoprotein Transport Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) QT interval ( 19305408)	Mean arterial pressure x educational attainment (some college) interaction (2df) ( 32372009) Metabolite levels ( 23823483) Visceral fat ( 30942860)
Interacting Genes		32 interacting genes: ASF1B CHAF1A CHAF1B CHEK2 H3-3A H3-4 H3C3 H3C6 H4C1 H4C11 H4C12 H4C13 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HTATIP2 MCM2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17	192 interacting genes: ABCG4 ACTR1B ADD1 AHDC1 AIDA AK3 ALKBH3 ANKRD50 ANXA11 APBB1IP ARFGAP3 ASF1A ASIC4 BCAS3 BEX2 BTF3 C1orf216 C20orf141 CBS CCDC120 CCDC7 CCNE2 CDSN CENPBD2P CHMP1A CIB1 CLRN3 CNDP2 CNKSR1 COG3 CSTA CTCFL CTHRC1 DALRD3 DELE1 DIXDC1 DLG4 DLK1 DR1 DTX3 E2F8 EDRF1 EEF1G ERCC6L EVL EXOSC9 EYA3 FAM9A FBH1 FOXD4L6 FTL FUT2 FUT9 GABPB1 GABPB2 GATA1 GOLPH3L GPR135 GRB10 GUSBP3 H2AP H2BC9 H3C10 HBG1 HECTD3 HLA-A HLA-DRB1 HMBS HOXA3 HS1BP3 HTT IFT20 IFT57 INPP5D JMJD7-PLA2G4B KHDC4 KIAA0408 KNSTRN KRAS KRT17 KRT8P12 KRTAP11-1 KRTAP9-2 LCA5L LCMT1P1 LGALS9C LIN28A LMAN2L LNCRI LRRC45 LY6G6C MANF MAP2K4 MAP3K19 MIIP MLH3 MRFAP1 MRFAP1L1 MSANTD3 MSRB2 MYBPHL MYOZ2 NCBP1 NEBL NFATC2IP NFYC NIFK NPFF ODF2 OFCC1 OTUD7B OTX2 PABIR3 PBRM1 PDZK1IP1 PHF5A PLEKHB1 PPP1R21 PPTC7 PRMT5 PTMA QRICH1 RAB39B RAD51 RANGRF RAP1B RBM5 RCAN3 RIC8A RNF20 RNF38 RSBN1L RUBCNL SCNM1 SEMA4G SF3A3 SHOX2 SKA3 SLC1A3 SLC25A31 SLC9A9 SLX9 SMARCB1 SNAP25 SOX14 SP2 SPRY3 SPRY4 SREBF2 SRSF4 STK25 STN1 SUMF2 SYT1 TEAD1 THAP7 TIGD1 TMC6 TMCC1 TMEM115 TMEM186 TMTC1 TNFAIP1 TNFSF10 TOX TPGS2 TTC23 TTLL7 TUT7 TXNDC12 TXNDC15 UBAC1 UBE2K USP18 USP32 VN1R10P VSX2 WAC WDR20 YIF1A YTHDF3 ZCCHC17 ZFC3H1 ZFP2 ZFP36 ZFYVE19 ZNF333 ZNF341 ZNF597 ZNF624 ZNF667-AS1 ZSCAN9
Entrez ID		25842	23390
HPRD ID		16459	09697
Ensembl ID		ENSG00000111875	ENSG00000186908
Uniprot IDs		Q9Y294	A8KA01 Q8IUH5
PDB IDs		1TEY 2I32 2IIJ 2IO5 3AAD 5C3I 6F0F 6F0G 6F0H 6ZUF 7LNY 7LO0 7V6Q 8BV1 8CJ1 8CJ2 8CJ3 8Z50	3EU9 5W7I 5W7J
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Nucleosome Organization Protein-DNA Complex Assembly CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Structural Constituent Of Chromatin Nucleosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Chromatin Organization Telomere Organization Chromatin Remodeling Chromosome, Telomeric Region Protein Localization To Chromatin Protein Heterodimerization Activity Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Protein-containing Complex Assembly Protein-containing Complex Chromosome Organization Protein-containing Complex Organization Chromosome Regulation Of Myeloid Cell Differentiation Cellular Component Assembly Regulation Of Hemopoiesis Extracellular Exosome Protein Localization To Organelle Nucleoplasm Negative Regulation Of Cell Differentiation DNA Binding DNA Replication-dependent Chromatin Assembly Regulation Of Cell Development Negative Regulation Of Developmental Process Intracellular Protein Localization Extracellular Region Organelle Organization RNA Binding Regulation Of Cell Differentiation Nucleus Regulation Of Multicellular Organismal Development Regulation Of Immune System Process CAF-1 Complex Regulation Of Developmental Process Histone Binding Protein Phosphorylation Protein Binding DNA Damage Response Phosphorylation RNA Polymerase II Core Promoter Sequence-specific DNA Binding	Protein Binding
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