ASF1A and CHAF1A

Number of citations of the paper that reports this interaction (PMID 11897662)
66

Data Source:
HPRD (in vivo)

		ASF1A	CHAF1A
Gene Name		anti-silencing function 1A histone chaperone	chromatin assembly factor 1, subunit A (p150)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein Complex	Nuclear Chromatin CAF-1 Complex Protein Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Chromatin Binding Protein Binding Identical Protein Binding Unfolded Protein Binding Chromo Shadow Domain Binding
	Biological Process	Osteoblast Differentiation DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Chromatin Modification Negative Regulation Of Chromatin Silencing Muscle Cell Differentiation	DNA Replication DNA Repair DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Cell Cycle Chromatin Assembly
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS		QT interval ( 19305408)
Protein-Protein Interactions		22 interactors: ASF1B CDAN1 CHAF1A CHAF1B CHEK2 H3F3A HIRA HIST1H3C HIST1H3E HIST1H4F HIST1H4L HIST3H3 HIST4H4 HTATIP2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17	37 interactors: ANP32A ANP32B ASF1A ASF1B BLM CBX1 CBX5 CDC7 CDK2 CHAF1B DBF4 DDX41 HIST1H3E HIST3H3 HMGB2 LZTR1 MBD1 MSH6 PABPC1 PCBD2 PCNA RBFOX2 REL SET SUMO1 SUMO2 SUMO3 TCERG1 TCF4 TRIM28 XRCC5 XRCC6 YWHAB YWHAE YWHAG YWHAQ ZNF408
Entrez ID		25842	10036
HPRD ID		16459	03148
Ensembl ID		ENSG00000111875	ENSG00000167670
Uniprot IDs		Q9Y294	Q13111
PDB IDs		1TEY 2I32 2IIJ 2IO5 3AAD
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Chromatin Assembly Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Nucleosome Assembly Nucleosome Organization Chromatin Organization DNA Conformation Change Chromosome Organization DNA Methylation On Cytosine Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Chromatin Silencing Cellular Macromolecular Complex Assembly Cellular Component Assembly Protein Complex Assembly DNA Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Organelle Organization Gene Silencing Histone H4-K20 Demethylation DNA Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Telomere Maintenance Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Metabolic Process Gene Expression Methylation CENP-A Containing Nucleosome Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation Regulation Of Chromatin Assembly Or Disassembly Centromere Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Demethylation	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Conformation Change Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Repair Protein-DNA Complex Assembly Chromosome Organization Nitrogen Compound Metabolic Process Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly Chromatin Assembly Nucleosome Organization Cellular Response To DNA Damage Stimulus Chromatin Assembly Or Disassembly Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process DNA Packaging Positive Regulation Of Metabolic Process Cellular Response To Stress Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Protein Sumoylation DNA Recombination Positive Regulation Of Intracellular Transport Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stress Telomere Maintenance Organelle Organization DNA Replication Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Macromolecule Biosynthetic Process Protein Complex Assembly Macromolecule Biosynthetic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Metabolic Process
Tagcloud ?		assembled caf chaperone chaperones dissect divergent enhances experiencing h4 hira histones involves mimetic newly nucleosomes organization phospho phosphorylated pocket restore shuttle stimulating supply tail timely tlk tlks tousled	3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst
Tagcloud (Difference) ?		assembled caf chaperone chaperones dissect divergent enhances experiencing h4 hira histones involves mimetic newly nucleosomes organization phospho phosphorylated pocket restore shuttle stimulating supply tail timely tlk tlks tousled	3a aggressive cohorts concept driven gsea intact malignancies malignancy mcm3 mcm6 mdm2 multifactorial networks neuroblastoma nutlin oncogene opposing overcome p53 potently reciprocally repressed repression rrm2 signature signatures subset worst
Tagcloud (Intersection) ?