ASF1A and TLK1

Number of citations of the paper that reports this interaction (PMID 11470414)
52

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ASF1A	TLK1
Gene Name		anti-silencing function 1A histone chaperone	tousled-like kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Protein Complex	Nucleus
	Molecular Function	Chromatin Binding Protein Binding Histone Binding	Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	Osteoblast Differentiation DNA Repair Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Chromatin Modification Negative Regulation Of Chromatin Silencing Muscle Cell Differentiation	Regulation Of Chromatin Assembly Or Disassembly Protein Phosphorylation Intracellular Protein Transport Cellular Response To DNA Damage Stimulus Cell Cycle Chromatin Modification Intracellular Signal Transduction
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS		QT interval ( 19305408)	Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		22 interactors: ASF1B CDAN1 CHAF1A CHAF1B CHEK2 H3F3A HIRA HIST1H3C HIST1H3E HIST1H4F HIST1H4L HIST3H3 HIST4H4 HTATIP2 PAFAH1B2 PRR3 ST13 TAF1 TLK1 TLK2 VPS28 ZDHHC17	13 interactors: ASF1A ASF1B AURKA CHEK1 HIST1H1A LUZP4 MBP NBN SNAP23 TLK2 TPM3 UBE3C YWHAE
Entrez ID		25842	9874
HPRD ID		16459	12232
Ensembl ID		ENSG00000111875	ENSG00000198586
Uniprot IDs		Q9Y294	Q9UKI8
PDB IDs		1TEY 2I32 2IIJ 2IO5 3AAD
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly Chromatin Assembly Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Nucleosome Assembly Nucleosome Organization Chromatin Organization DNA Conformation Change Chromosome Organization DNA Methylation On Cytosine Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Chromatin Silencing Cellular Macromolecular Complex Assembly Cellular Component Assembly Protein Complex Assembly DNA Methylation Negative Regulation Of Gene Expression, Epigenetic DNA Modification Organelle Organization Gene Silencing Histone H4-K20 Demethylation DNA Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Telomere Maintenance Regulation Of Megakaryocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Metabolic Process Gene Expression Methylation CENP-A Containing Nucleosome Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Histone Lysine Demethylation Histone Demethylation Protein Demethylation Regulation Of Chromatin Assembly Or Disassembly Centromere Complex Assembly Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Demethylation	Chromosome Organization Chromatin Organization Organelle Organization Chromatin Modification DNA Conformation Change DNA Replication-dependent Nucleosome Assembly Positive Regulation Of Gene Expression, Epigenetic G2/M Transition Of Mitotic Cell Cycle Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Protein Complex Assembly DNA Packaging Histone Phosphorylation DNA Replication-independent Nucleosome Assembly G2 DNA Damage Checkpoint Substantia Nigra Development Cellular Macromolecular Complex Assembly Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Cell Cycle Phase Transition Regulation Of Centrosome Cycle Cell Cycle Neural Nucleus Development Mitotic Cell Cycle Response To Stress Negative Regulation Of Spindle Checkpoint Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Organelle Organization Midbrain Development Regulation Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Spindle Assembly Involved In Female Meiosis I Regulation Of Heart Rate By Hormone Histone H3-T11 Phosphorylation Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Cell Cycle Cell Cycle Process Reproduction Defense Response To Nematode Spindle Assembly Involved In Meiosis Peptidyl-serine Phosphorylation Cellular Component Assembly Regulation Of Cellular Component Organization Regulation Of Mitotic Nuclear Division Regulation Of Cellular Protein Metabolic Process Spindle Stabilization
Tagcloud ?		assembled caf chaperone chaperones dissect divergent enhances experiencing h4 hira histones involves mimetic newly nucleosomes organization phospho phosphorylated pocket restore shuttle stimulating supply tail timely tlk tlks tousled	asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 tlks tousled yielded
Tagcloud (Difference) ?		assembled caf chaperone chaperones dissect divergent enhances experiencing h4 hira histones involves mimetic newly nucleosomes organization phospho phosphorylated pocket restore shuttle stimulating supply tail timely tlk	asymmetric belonging cloned coefficient crystallization crystals cubic diffracting diffraction evolutionarily hetero homo homogeneity i4122 localize matthews namely oligomers p213 purification segregation solvent synchrotron tetragonal threonine tlk2 yielded
Tagcloud (Intersection) ?		tlks tousled