CLNS1A and PRMT5

Number of citations of the paper that reports this interaction (PMID 11756452)
51

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CLNS1A	PRMT5
Gene Name		chloride channel, nucleotide-sensitive, 1A	protein arginine methyltransferase 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Methylosome PICln-Sm Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	Protein Binding Poly(A) RNA Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process	Spliceosomal SnRNP Assembly Chloride Transport Cell Volume Homeostasis Gene Expression NcRNA Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways		snRNP Assembly Metabolism of non-coding RNA	Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 ITGA2B LSM10 LSM2 LSM3 LSM6 PRMT5 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		1207	10419
HPRD ID		03694	04955
Ensembl ID		ENSG00000074201	ENSG00000100462
Uniprot IDs		E9PJF4 P54105	O14744
PDB IDs			4GQB
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Histone MRNA Metabolic Process MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing DNA-templated Transcription, Termination NcRNA Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cortical Actin Cytoskeleton Organization RNA Biosynthetic Process Cortical Cytoskeleton Organization Aromatic Compound Catabolic Process Platelet Aggregation Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RNA-directed RNA Polymerase Activity Neuron Projection Morphogenesis Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cellular Macromolecule Catabolic Process Cell Part Morphogenesis Regulation Of Mitotic Cell Cycle	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?			acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?