CLNS1A and ITGA2B

Number of citations of the paper that reports this interaction (PMID 15075326)
11

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		CLNS1A	ITGA2B
Gene Name		chloride channel, nucleotide-sensitive, 1A	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Methylosome PICln-Sm Protein Complex	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Spliceosomal SnRNP Assembly Chloride Transport Cell Volume Homeostasis Gene Expression NcRNA Metabolic Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Platelet Activation Extracellular Matrix Organization Platelet Aggregation
Pathways		snRNP Assembly Metabolism of non-coding RNA	Signal transduction by L1 Axon guidance p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Abciximab Tirofiban
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 ITGA2B LSM10 LSM2 LSM3 LSM6 PRMT5 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG	15 interactors: AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA GRB2 ITGB3 PRKACA TLN1 VWF
Entrez ID		1207	3674
HPRD ID		03694	06377
Ensembl ID		ENSG00000074201	ENSG00000005961
Uniprot IDs		E9PJF4 P54105	P08514
PDB IDs			1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2
Enriched GO Terms of Interacting Partners?		MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome Spliceosomal SnRNP Assembly RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Histone MRNA Metabolic Process MRNA 3'-end Processing Termination Of RNA Polymerase II Transcription Ribonucleoprotein Complex Assembly Ribonucleoprotein Complex Biogenesis RNA 3'-end Processing DNA-templated Transcription, Termination NcRNA Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecular Complex Assembly Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Assembly Nucleobase-containing Compound Metabolic Process Cellular Component Assembly Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Cortical Actin Cytoskeleton Organization RNA Biosynthetic Process Cortical Cytoskeleton Organization Aromatic Compound Catabolic Process Platelet Aggregation Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of RNA-directed RNA Polymerase Activity Neuron Projection Morphogenesis Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Neuron Projection Development Axon Guidance Cell Projection Morphogenesis Cellular Macromolecule Catabolic Process Cell Part Morphogenesis Regulation Of Mitotic Cell Cycle	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Platelet Degranulation Response To Stress Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Leukocyte Migration Cellular Response To Organic Substance Cellular Component Assembly Regulation Of Blood Coagulation Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Signaling Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Cellular Protein Metabolic Process Platelet Aggregation Cell Adhesion Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Cardiovascular System Development Positive Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Transport Secretion By Cell Movement Of Cell Or Subcellular Component
Tagcloud ?			actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Difference) ?			actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Intersection) ?