CLNS1A and EPB41

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vitro, two hybrid)

		CLNS1A	EPB41
Description		chloride nucleotide-sensitive channel 1A	erythrocyte membrane protein band 4.1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Methylosome PICln-Sm Protein Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Binding Protein Binding	Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Cytoskeletal Protein Binding Spectrin Binding Phosphoprotein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Processing Chloride Transport Cell Volume Homeostasis RNA Splicing MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome	Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Regulation Of Calcium Ion Transport Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex
Pathways		snRNP Assembly	Neurexins and neuroligins
Drugs
Diseases			Hereditary elliptocytosis (HE)
GWAS		Diastolic blood pressure ( 30224653) Platelet distribution width ( 32888494) Tourette syndrome ( 30818990)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) HDL levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		14 interacting genes: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 FRMD7 ITGA2B LARP1 LSM10 PRMT5 SNRPB SNRPD1 UBC WDR77	40 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CLNS1A CPAP CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RNF10 RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		1207	2035
HPRD ID		03694	00558
Ensembl ID		ENSG00000074201	ENSG00000159023
Uniprot IDs		E9PJF4 E9PMI6 J3KN38 P54105	A0A2R8Y5G2 A0A2R8Y5Z6 A0A2R8Y6D0 A0A2R8Y7Y3 A0A2R8YD30 A0A2U3TZH6 A0A994J847 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		6V0O 9E3A 9E3B	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?		Methylosome Spliceosomal SnRNP Assembly Histone Pre-mRNA DCP Binding U7 SnRNP U1 SnRNP Binding Protein-RNA Complex Assembly 7-methylguanosine Cap Hypermethylation Regulation Of Dopamine Receptor Signaling Pathway U4 SnRNP Structural Constituent Of Cytoskeleton Small Nuclear Ribonucleoprotein Complex Regulation Of Translational Initiation SMN-Sm Protein Complex Macromolecule Methylation U1 SnRNP U5 SnRNP Cytosol U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Regulation Of Protein Localization To Cell Periphery Cortical Cytoskeleton Ribonucleoprotein Complex Cortical Actin Cytoskeleton Organization U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U2 SnRNP Methyl-CpG Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Methylation U4/U6 X U5 Tri-snRNP Complex Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Response To Environmental Enrichment Negative Regulation Of Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Cortical Cytoskeleton Organization Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Methylation Positive Regulation Of RNA Splicing Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Oocyte Axis Specification Cytoplasmic U SnRNP Body RNA Binding Protein Metabolic Process MRNA Metabolic Process Regulation Of Norepinephrine Uptake Swimming Behavior Cytoskeletal Protein Binding U2 SnRNP Binding	Structural Constituent Of Cytoskeleton Spectrin Regulation Of Protein Localization Regulation Of Supramolecular Fiber Organization Cortical Cytoskeleton Protein-containing Complex GMP Kinase Activity Muscle System Process Astral Microtubule Organization GDP Metabolic Process Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Localization Cell Junction Negative Regulation Of Cytosolic Calcium Ion Concentration Muscle Contraction Ankyrin Binding Regulation Of Neurotransmitter Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Intracellular Signaling Cassette Cytoskeletal Protein Binding Regulation Of Cytoskeleton Organization Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Actin Filament Organization Regulation Of Transport GMP Metabolic Process Regulation Of Monoatomic Ion Transport Positive Regulation Of Supramolecular Fiber Organization Regulation Of Potassium Ion Transport Cytosol Dopamine Neurotransmitter Receptor Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Regulation Of Protein Transport Actin Filament Capping Regulation Of Cellular Component Organization Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Pre-mRNA 3'-splice Site Binding U2AF Complex System Process Cadherin Binding Positive Regulation Of Transport Actin Filament Binding Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Cell Cycle Ankyrin-1 Complex Extracellular Exosome Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Protein Localization
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