CLK3

Description		CDC like kinase 3
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GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Cytoplasmic Vesicle Intermediate Filament Cytoskeleton
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Regulation Of RNA Splicing
Pathways
Drugs		K-00546 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712)
Interacting Genes		43 interacting genes: APP CHERP CLASRP CLK2 DDIT4L EIF4ENIF1 HNRNPR HOXB6 HOXB7 HOXC4 INCA1 KRTAP10-3 LNX1 NEDD4 NKAPL NXF1 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RNF8 RNPS1 RSRP1 SAG SDCBP SH2B2 SLAMF7 SNRNP35 SRPK2 SRSF1 SRSF10 SRSF3 SRSF8 SUV39H1 TINF2 TRA2B USP13 YWHAG ZNF263 ZNF473 ZNF777 ZNF835
Entrez ID		1198
HPRD ID		04290
Ensembl ID		ENSG00000179335
Uniprot IDs		B3KRI8 P49761
PDB IDs		2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT 6YTW 6YTY 6YU1 6Z2V 6Z51 6Z52 6Z53 6Z54 6Z55 9EZ3
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Processing RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process MRNA Binding RNA Processing MRNA Metabolic Process Nucleic Acid Binding Positive Regulation Of RNA Splicing RNA Metabolic Process Nucleus Nucleoplasm RNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nuclear Speck Positive Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Splicing RS Domain Binding Protein-RNA Complex Assembly Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Pre-mRNA Binding Identical Protein Binding Embryonic Skeletal System Morphogenesis Exon-exon Junction Complex
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