CLK3 and USP13

Number of citations of the paper that reports this interaction (PubMedID 32453420)
32

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)

		CLK3	USP13
Description		CDC like kinase 3	ubiquitin specific peptidase 13
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Cytoplasmic Vesicle Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Protein-folding Chaperone Binding Proteasome Binding BAT3 Complex Binding K48-linked Deubiquitinase Activity
	Biological Process	Protein Phosphorylation Regulation Of RNA Splicing	Regulation Of DNA-templated Transcription Proteolysis Autophagy Cell Population Proliferation Regulation Of Autophagy Protein Deubiquitination Melanocyte Differentiation Regulation Of Protein Stability Protein K29-linked Deubiquitination Maintenance Of Unfolded Protein Protein K6-linked Deubiquitination Protein Stabilization Protein K63-linked Deubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		K-00546 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712)
Interacting Genes		43 interacting genes: APP CHERP CLASRP CLK2 DDIT4L EIF4ENIF1 HNRNPR HOXB6 HOXB7 HOXC4 INCA1 KRTAP10-3 LNX1 NEDD4 NKAPL NXF1 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RNF8 RNPS1 RSRP1 SAG SDCBP SH2B2 SLAMF7 SNRNP35 SRPK2 SRSF1 SRSF10 SRSF3 SRSF8 SUV39H1 TINF2 TRA2B USP13 YWHAG ZNF263 ZNF473 ZNF777 ZNF835	25 interacting genes: AMFR ATG5 CCND1 CLK3 CSNK2A1 CTNNB1 DAZAP2 DVL1 DYRK1A FNBP1L FUNDC2 G3BP1 LAPTM5 MDC1 MRPL20 MYO15A SIAH2 SPRR2C TOPBP1 TRIM55 TRIM63 TWIST1 UBC UBL4A UIMC1
Entrez ID		1198	8975
HPRD ID		04290	04666
Ensembl ID		ENSG00000179335	ENSG00000058056
Uniprot IDs		B3KRI8 P49761	A0A0A6YZ17 Q92995
PDB IDs		2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT 6YTW 6YTY 6YU1 6Z2V 6Z51 6Z52 6Z53 6Z54 6Z55 9EZ3	2L80 2LBC
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Processing RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process MRNA Binding RNA Processing MRNA Metabolic Process Nucleic Acid Binding Positive Regulation Of RNA Splicing RNA Metabolic Process Nucleus Nucleoplasm RNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nuclear Speck Positive Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Splicing RS Domain Binding Protein-RNA Complex Assembly Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Pre-mRNA Binding Identical Protein Binding Embryonic Skeletal System Morphogenesis Exon-exon Junction Complex	DNA Damage Checkpoint Signaling Protein Modification Process Wnt Signaling Pathway Protein Ubiquitination Mitotic DNA Integrity Checkpoint Signaling Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Autophagic Cell Death Autophagy Protein Localization To Site Of Double-strand Break Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Intracellular Signal Transduction Negative Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Protein Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Post-translational Protein Modification Chaperone-mediated Autophagy Positive Regulation Of Stress Granule Assembly Negative Regulation Of Signal Transduction By P53 Class Mediator Post-translational Protein Modification Response To Stress Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cell Cycle Process Identical Protein Binding Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Double-strand Break Repair Via Nonhomologous End Joining Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of Stress Granule Assembly Ubiquitin Protein Ligase Binding Regulation Of DNA Metabolic Process Genitalia Morphogenesis Regulation Of Wnt Signaling Pathway Cellular Response To Stress Negative Regulation Of Wnt Signaling Pathway Wnt Signalosome Cardiac Muscle Cell Apoptotic Process Catabolic Process Protein Serine/threonine Kinase Activator Activity Nucleus Aggrephagy Striated Muscle Cell Apoptotic Process Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Protein-containing Complex Macromolecule Catabolic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catabolic Process
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