CLK3 and PRMT5

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		CLK3	PRMT5
Gene Name		CDC-like kinase 3	protein arginine methyltransferase 5
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Membrane Nuclear Speck Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Ribonucleoprotein Complex Binding
	Biological Process	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Cell Proliferation Gene Expression Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression NcRNA Metabolic Process Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation
Pathways			Chromatin modifying enzymes snRNP Assembly Chromatin organization Metabolism of non-coding RNA RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: APP CLK2 HOXB6 HOXB7 KRTAP10-3 NEDD4 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RSRP1 SDCBP SLAMF7 SRPK2 SUV39H1 TINF2 YWHAG ZNF263	67 interactors: ARGLU1 CALU CAPN1 CCAR2 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A EZH2 FAM76B GRHL3 GTPBP2 H3F3C HIST1H3A HIST1H4A HIST2H2AC HOXC4 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NELFCD NUDCD2 OLA1 PHYHIP PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SSTR1 SUPT5H TRIB3 TYK2 WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUFSP
Entrez ID		1198	10419
HPRD ID		04290	04955
Ensembl ID		ENSG00000179335	ENSG00000100462
Uniprot IDs		B3KRI8 B3KTV2 P49761	O14744
PDB IDs		2EU9 2EXE 2WU6 2WU7 3RAW	4GQB
Enriched GO Terms of Interacting Partners?		MRNA Processing Regulation Of RNA Splicing MRNA Metabolic Process RNA Metabolic Process RNA Processing RNA Splicing Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Gene Expression Regulation Of MRNA Processing Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Biosynthetic Process Immune System Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Neuromuscular Junction Development Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Nuclear Speck Organization Transmission Of Virus Development Involved In Symbiotic Interaction Cellular Metabolic Process Cell Activation Regulation Of Cellular Process Cell Differentiation Cellular Component Assembly Ribonucleoprotein Complex Biogenesis Regulation Of Protein ADP-ribosylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Synaptic Growth At Neuromuscular Junction Immune Response Negative Regulation Of Gene Expression Regulation Of Synapse Structure Or Activity Innate Immune Response Collateral Sprouting In Absence Of Injury Positive Regulation Of Organelle Organization Positive Regulation Of Extracellular Vesicular Exosome Assembly Negative Regulation Of Protein Glycosylation Protein Targeting Regulation Of Organelle Organization Histone Methylation	Gene Expression RNA Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Organization Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Chromatin Modification Regulation Of RNA Metabolic Process MRNA Processing Nitrogen Compound Metabolic Process Regulation Of Gene Expression Chromosome Organization Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated MRNA Metabolic Process RNA Splicing RNA Biosynthetic Process RNA Processing Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of Transcription, DNA-templated MRNA Splicing, Via Spliceosome Regulation Of Nucleic Acid-templated Transcription RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Assembly Spliceosomal SnRNP Assembly Positive Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Ribonucleoprotein Complex Biogenesis Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Peptidyl-amino Acid Modification Positive Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Chromatin Remodeling Regulation Of Metabolic Process Positive Regulation Of Viral Transcription Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Nucleosome Disassembly Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Difference) ?			acquisition af9 arginine biomedical bypassing cooperates critically drive drivers forming inactivating inherent lymphomagenesis lymphomas mll modulator neoplastic notch1 oncogenic overt relevance renewal revealing selectively specimen supporting suppresses sustaining transferase
Tagcloud (Intersection) ?