SRRM1 and SPOP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SRRM1	SPOP
Gene Name		serine/arginine repetitive matrix 1	speckle-type POZ protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	DNA Binding Poly(A) RNA Binding	RNA Polymerase II Transcription Factor Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	Glucose Homeostasis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Hedgehog 'on' state Signaling by Hedgehog
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		11 interactors: ABI1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 YWHAG	19 interactors: AR BRMS1 DAXX DDIT3 DPPA2 FADD GIT2 H2AFY HCST MYD88 PDX1 PIAS1 RTN3 RXRB SRRM1 TRAF1 TRAF6 UBE2E3 ZBTB16
Entrez ID		10250	8405
HPRD ID		10441	16004
Ensembl ID		ENSG00000133226	ENSG00000121067
Uniprot IDs		E9PCT1 Q8IYB3	O43791
PDB IDs		1MP1	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing RNA Splicing MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Viral Process Negative Regulation Of Viral Process Regulation Of MRNA Processing Phosphorylation Cellular Protein Metabolic Process Cellular Metabolic Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Nucleus Organization Regulation Of Mitotic Nuclear Division RNA Metabolic Process Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Gene Expression Lamellipodium Morphogenesis Regulation Of Viral Process Defense Response Positive Regulation Of Cell Death Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Death Sperm Chromatin Condensation Protein Metabolic Process Signaling Regulation Of Metabolic Process Regulation Of Cell Division Negative Regulation Of Gluconeogenesis Cell Communication Phosphate-containing Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Organelle Organization Megakaryocyte Development	Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Death Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Transcription, DNA-templated Androgen Receptor Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Apoptotic Process Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Proliferation Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Transcription From RNA Polymerase II Promoter JNK Cascade RNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Activation
Tagcloud ?			amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?			amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening pik3cb qiagen read routinely screen sections technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?