SRRM1 and SRRM2

Number of citations of the paper that reports this interaction (PMID 9531537)
65

Data Source:
BioGRID (affinity chromatography technology, biochemical, biochemical)
HPRD (in vivo)

		SRRM1	SRRM2
Gene Name		serine/arginine repetitive matrix 1	serine/arginine repetitive matrix 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome	Nucleoplasm Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	DNA Binding Poly(A) RNA Binding	Poly(A) RNA Binding Protein N-terminus Binding C2H2 Zinc Finger Domain Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ABI1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 YWHAG	12 interactors: APP CSNK2A1 PIN1 PNN PRPF6 SNIP1 SRRM1 SRSF4 TTC14 XRN1 YWHAB YWHAG
Entrez ID		10250	23524
HPRD ID		10441	06913
Ensembl ID		ENSG00000133226	ENSG00000167978
Uniprot IDs		E9PCT1 Q8IYB3	Q9UQ35
PDB IDs		1MP1
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing RNA Splicing MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Viral Process Negative Regulation Of Viral Process Regulation Of MRNA Processing Phosphorylation Cellular Protein Metabolic Process Cellular Metabolic Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Nucleus Organization Regulation Of Mitotic Nuclear Division RNA Metabolic Process Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Gene Expression Lamellipodium Morphogenesis Regulation Of Viral Process Defense Response Positive Regulation Of Cell Death Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Death Sperm Chromatin Condensation Protein Metabolic Process Signaling Regulation Of Metabolic Process Regulation Of Cell Division Negative Regulation Of Gluconeogenesis Cell Communication Phosphate-containing Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Organelle Organization Megakaryocyte Development	MRNA Metabolic Process RNA Processing MRNA Processing Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA Metabolic Process RNA Splicing RNA 3'-end Processing RNA Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Cellular Nitrogen Compound Metabolic Process Intracellular Transport Negative Regulation Of Cellular Protein Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination Negative Regulation Of Protein Metabolic Process RNA Export From Nucleus Regulation Of Organelle Organization Axon Guidance Nitrogen Compound Metabolic Process Apoptotic Process Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Mitochondrion Organization Regulation Of Metabolic Process Synaptic Growth At Neuromuscular Junction Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle Process Establishment Of Localization In Cell Regulation Of RNA Metabolic Process Nuclear Export MRNA Transport Cellular Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Mitotic Nuclear Division Axonogenesis Positive Regulation Of Protein Metabolic Process
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