SRRM1 and DEK

Number of citations of the paper that reports this interaction (PubMedID 10908574)
79

Data Source:
HPRD (in vitro)

		SRRM1	DEK
Description		serine and arginine repetitive matrix 1	DEK proto-oncogene
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Contractile Muscle Fiber B-WICH Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding	DNA Binding RNA Binding Protein Binding Histone Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome	Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Male-pattern baldness ( 28196072) Systolic blood pressure ( 29208002)	Atrial fibrillation ( 30061737) Metabolite levels ( 23823483) PR interval ( 32439900)
Interacting Genes		13 interacting genes: ABI1 CLK1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 SRRM4 YWHAG	16 interacting genes: AP2A1 CDC42 CEBPA CREBBP CSNK2A1 EP300 GPATCH11 H3-4 HLA-A KAT2B OGT SRRM1 TFAP2A TRIM55 TRIM63 ZIK1
Entrez ID		10250	7913
HPRD ID		10441	00503
Ensembl ID		ENSG00000133226	ENSG00000124795
Uniprot IDs		A0A0S2Z4W1 A0A0S2Z4Z6 A0A994J4Y3 A0A994J7H1 A0A994J7V4 B7Z7U0 Q8IYB3	H0Y8X0 P35659
PDB IDs		1MP1 6FF4 6FF7 7ABG 7ABH 7ABI 7DVQ 8I0P 8I0R	1Q1V 2JX3 8KCY 8KD1
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nuclear Speck Regulation Of Primary Metabolic Process Nucleus Protein Serine Kinase Activity RNA Splicing Protein Serine/threonine Kinase Activity Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Regulation Of Metabolic Process Macromolecule Metabolic Process RNA Binding MRNA Metabolic Process Kinase Activity Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Double-strand Break Repair Protein Serine/threonine/tyrosine Kinase Activity Postsynaptic Cytosol Positive Regulation Of Viral Genome Replication MRNA Processing Regulation Of Gene Expression RNA Metabolic Process RNA Processing Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Protein Targeting Nucleoplasm Negative Regulation Of Translational Initiation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Regulation Of DNA Repair Protein Modification Process Protein Stabilization Cis-trans Isomerase Activity Positive Regulation Of Viral Process Identical Protein Binding Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Phosphorylation Protein Localization To Vacuole Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Nucleic Acid Metabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Protein Kinase C Inhibitor Activity ATP Binding	N-terminal Peptidyl-lysine Acetylation Histone Acetyltransferase Complex Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Acetyltransferase Activity Histone H3K27 Acetyltransferase Activity Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Chromatin DNA Binding Protein-lysine-acetyltransferase Activity Histone H3K18 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Activity Protein Acetylation Rhythmic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein Maturation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Gluconeogenesis Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Canonical NF-kappaB Signal Transduction DNA-binding Transcription Factor Binding Regulation Of Transcription By Glucose Internal Protein Amino Acid Acetylation STAT Family Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Chromatin Binding Regulation Of Cellular Response To Heat Response To Nutrient Levels Cellular Response To Nutrient Levels Positive Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Learning Or Memory Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Negative Regulation Of Small Molecule Metabolic Process Sin3-type Complex Regulation Of Attachment Of Spindle Microtubules To Kinetochore Memory Cognition Transcription Coregulator Activity Negative Regulation Of Transcription By RNA Polymerase II
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