SRRM1 and FUS

Number of citations of the paper that reports this interaction (PMID 12581738)
24

Data Source:
HPRD (in vitro, in vivo)

		SRRM1	FUS
Gene Name		serine/arginine repetitive matrix 1	FUS RNA binding protein
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA Binding Poly(A) RNA Binding	Nucleotide Binding DNA Binding RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ABI1 CLK2 CSNK2A1 DEK FUS PIN1 SPOP SRPK1 SRPK2 SRRM2 YWHAG	39 interactors: ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 PA2G4 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SUV39H1 TAF15 TARDBP TDRD3 THRA TNIP1 WBP4 YBX1 ZMYM2
Entrez ID		10250	2521
HPRD ID		10441	00660
Ensembl ID		ENSG00000133226	ENSG00000089280
Uniprot IDs		E9PCT1 Q8IYB3	P35637 Q13344 Q6IBQ5
PDB IDs		1MP1	2LA6 2LCW 4FDD 4FQ3
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing RNA Splicing MRNA Processing Positive Regulation Of Viral Genome Replication MRNA Metabolic Process RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Protein Modification Process Protein Phosphorylation Negative Regulation Of Viral Genome Replication Innate Immune Response Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Viral Genome Replication Nuclear Speck Organization Positive Regulation Of Viral Process Negative Regulation Of Viral Process Regulation Of MRNA Processing Phosphorylation Cellular Protein Metabolic Process Cellular Metabolic Process Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Nucleus Organization Regulation Of Mitotic Nuclear Division RNA Metabolic Process Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Gene Expression Lamellipodium Morphogenesis Regulation Of Viral Process Defense Response Positive Regulation Of Cell Death Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Apoptotic Process Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Death Sperm Chromatin Condensation Protein Metabolic Process Signaling Regulation Of Metabolic Process Regulation Of Cell Division Negative Regulation Of Gluconeogenesis Cell Communication Phosphate-containing Compound Metabolic Process Peptidyl-tyrosine Phosphorylation Regulation Of Organelle Organization Megakaryocyte Development	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process RNA Splicing Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process MRNA Processing Transcription From RNA Polymerase II Promoter Biosynthetic Process MRNA Metabolic Process Regulation Of Transcription, DNA-templated RNA Processing Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Splicing Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Transcription, DNA-templated MRNA Export From Nucleus RNA Export From Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter
Tagcloud ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Difference) ?			antitrypsin chn chondrosarcoma desmin desmoplastic ectomesenchymoma etv1 ews extraskeletal fkhr fli1 hhf35 liposarcoma mic2 myod1 myxoid p22 pax pnet q12 q14 q22 q24 q35 ssx1 stt stts syt tec witnessed
Tagcloud (Intersection) ?