ADD1 and SPTAN1

Number of citations of the paper that reports this interaction (PMID 8663089)
12

Data Source:
BioGRID (pull down)

		ADD1	SPTAN1
Gene Name		adducin 1 (alpha)	spectrin, alpha, non-erythrocytic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Focal Adhesion F-actin Capping Protein Complex Postsynaptic Density Dendritic Spine Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Molecule Activity Calmodulin Binding Transcription Factor Binding Spectrin Binding T Cell Receptor Binding Protein Homodimerization Activity Poly(A) RNA Binding Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Cell Morphogenesis In Utero Embryonic Development Cell Volume Homeostasis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Hemoglobin Metabolic Process Actin Cytoskeleton Organization Erythrocyte Differentiation Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Binding Multicellular Organism Growth Cellular Protein Metabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Endocytosis Homeostasis Of Number Of Cells Within A Tissue Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Cellular Response To Retinoic Acid	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways		Apoptotic cleavage of cellular proteins IRE1alpha activates chaperones Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)	Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		21 interactors: ADD2 ATP1A1 CALM1 CASP3 CSNK2B GEMIN7 HMG20A HSPH1 ID2 ID3 MAP1LC3B PRKACA PRKCD RFX1 ROCK1 SMARCC1 SPTA1 SPTAN1 SPTB TK1 ZDHHC17	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		118	6709
HPRD ID		00036	01684
Ensembl ID		ENSG00000087274	ENSG00000197694
Uniprot IDs		A2A3N8 P35611 Q86XM2	Q13813
PDB IDs			2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Actin Filament Polymerization Response To External Stimulus Negative Regulation Of Protein Polymerization Regulation Of Actin Filament-based Process Regulation Of Binding Nervous System Development Negative Regulation Of Protein Complex Assembly Actin Filament Capping Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Negative Regulation Of Actin Filament Depolymerization Negative Regulation Of Cytoskeleton Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Depolymerization Execution Phase Of Apoptosis Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length System Development Negative Regulation Of Protein Complex Disassembly Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Regulation Of Cell Activation Regulation Of Protein Depolymerization Neuron Differentiation Generation Of Neurons Developmental Process Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Disassembly Multicellular Organismal Development Immune System Process Neurogenesis Anatomical Structure Development Cellular Metabolic Process Regulation Of Protein Binding Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Chemotaxis Regulation Of Cell Adhesion Activation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Cell-cell Adhesion Positive Regulation Of Phospholipase C Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Cell Morphogenesis Involved In Differentiation Negative Regulation Of Glial Cell Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cardiac Muscle Contraction Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase Activity	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?		arnt2 asked camk2g cstb ctgf downregulated dr1 epas1 globin gna11 hif1a hypoxic il6st khsrp mars multitude neuroglobin neuroprotection ngb o4 ogd pea15 r4 reoxygenation rest spatially temporally tg wt	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?